STARD13 - StAR related lipid transfer domain containing 13 Gene

中文名称：含 StAR 相关脂质转移结构域 13

种属: Homo sapiens

同用名: DLC2; GT650; ARHGAP37; LINC00464

基因 ID: 90627 | 基因类型: protein coding

关于 STARD13

Cytogenetic location: 13q13.1-q13.2 Genomic coordinates (GRCh38): 13:33,103,137-33,676,794 (from NCBI)

This gene has 9 transcripts (splice variants), 223 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 9.3), thyroid (RPKM 7.8) and 24 other tissues.

功能概要

该基因编码的蛋白质包含一个用于蛋白质-蛋白质相互作用的 N 末端不育 α 基序 (SAM) ，然后是一个 ATP/GTP 结合基序、一个 GTP 酶激活蛋白 (GAP) 结构域和一个 C 末端 STAR-相关脂质转移 (START) 结构域。它可能参与细胞骨架重组、细胞增殖和细胞运动的调节，并在肝癌细胞中充当肿瘤抑制因子。该基因位于 13 号染色体的一个区域，该区域与肝细胞癌中的杂合性缺失有关。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

STARD13 基因产物(7)

mRNA	Protein	Name
NM_001243466.2	NP_001230395.1	stAR-related lipid transfer protein 13 isoform 5
NM_001243474.2	NP_001230403.1	stAR-related lipid transfer protein 13 isoform 6
NM_001243476.3	NP_001230405.1	stAR-related lipid transfer protein 13 isoform 4
NM_001411014.1	NP_001397943.1	stAR-related lipid transfer protein 13 isoform 7
NM_052851.3	NP_443083.1	stAR-related lipid transfer protein 13 isoform 3
NM_178006.4	NP_821074.1	stAR-related lipid transfer protein 13 isoform 1
NM_178007.3	NP_821075.1	stAR-related lipid transfer protein 13 isoform 2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	14697242	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within endothelial cell migration	IGI IGI: 通过遗传相互作用推断	20208559	GOA
acts upstream of or within endothelial cell migration	IMP IMP: 通过突变表型推断	20208559	GOA
acts upstream of or within endothelial tube lumen extension	IGI IGI: 通过遗传相互作用推断	20208559	GOA
acts upstream of or within endothelial tube lumen extension	IMP IMP: 通过突变表型推断	20208559	GOA
acts upstream of or within negative regulation of cell migration involved in sprouting angiogenesis	IGI IGI: 通过遗传相互作用推断	20208559	GOA
acts upstream of or within negative regulation of cell migration involved in sprouting angiogenesis	IMP IMP: 通过突变表型推断	20208559	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STARD13 蛋白结构

SAM_2

RhoGAP

START

0
200
400
600
800
1000
1113 a.a.

蛋白主名

其他名称

stAR-related lipid transfer protein 13

Rho GTPase activating protein on chromosome 13q12

STARD13 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	STARD13	Q9Y3M8	TAX1BP1	Homo sapiens	Q86VP1	Anti Tag CoIP	14697242
种属内	STARD13	Q9Y3M8	TAX1BP1	Homo sapiens	Q86VP1	Y2H	14697242

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13877	STARD13 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	STARD13	VGNC	VGNC:65752
Mus musculus	STARD13	MGD	MGI:2385331
Macaca mulatta	STARD13	VGNC	VGNC:77962
Canis familiaris	STARD13	VGNC	VGNC:46881
Bos taurus	STARD13	VGNC	VGNC:35362
Rattus norvegicus	STARD13	RGD	RGD:1564816

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

STARD13 - StAR related lipid transfer domain containing 13 Gene

关于 STARD13

功能概要

STARD13 基因产物(7)

STARD13 蛋白结构

STARD13 蛋白互作信息

关联疾病

直系同源

热门区域

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STARD13 - StAR related lipid transfer domain containing 13 Gene

关于 STARD13

功能概要

STARD13 基因产物(7)

STARD13 蛋白结构

STARD13 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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F

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J

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