2. Gene
  3. MAP3K6 - mitogen-activated protein kinase kinase kinase 6 Gene

MAP3K6 - mitogen-activated protein kinase kinase kinase 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶激酶激酶 6

种属: Homo sapiens

同用名: ASK2; MEKK6; MAPKKK6

基因 ID: 9064 | 基因类型: protein coding

关于 MAP3K6

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,355,184-27,366,961 (from NCBI)

This gene has 8 transcripts (splice variants), 193 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 18.7), fat (RPKM 11.6) and 21 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸蛋白激酶，形成蛋白激酶介导的信号转导级联的一个组成部分。编码的激酶参与血管内皮生长因子 (VEGF) 表达的调节。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 7 月]

This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

MAP3K6 基因产物(2)

mRNA Protein Name
NM_001297609.2 NP_001284538.1 mitogen-activated protein kinase kinase kinase 6 isoform 2
NM_004672.5 NP_004663.3 mitogen-activated protein kinase kinase kinase 6 isoform 1

MAP3K6 蛋白结构

DUF4071

DUF4071: Domain of unknown function (DUF4071) (129 - 507)

Pkinase

Pkinase: Protein kinase domain (653 - 906)

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  • 1288 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase 6

apoptosis signal-regulating kinase 2

关联疾病

疾病名称 别名
Diffuse Gastric And Lobular Breast Cancer Syndrome

Hereditary Diffuse Gastric Cancer

HDGC

LBC

Familial Diffuse Gastric Cancer

Fdgc

Hereditary Diffuse Gastric Adenocarcinoma

Breast Cancer, Lobular

Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate

DGLBC

Gastric Cancer, Hereditary Diffuse

Gastric Cancer, Familial Diffuse Breast Cancer, Lobular

Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate

E-Cadherin-Associated Hereditary Gastric Cancer

Familial Diffuse Cancer Of Stomach

Hereditary Diffuse Cancer Of Stomach

Gastric Cancer Familial Diffuse

Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate

Cancer, Gastric, Hereditary Diffuse
Diffuse Gastric Cancer

Hereditary Diffuse Gastric Adenocarcinoma

Hereditary Diffuse Gastric Cancer

Signet Cell Adenocarcinoma

Signet Ring Cell Carcinoma

Signet Ring Cell Gastric Carcinoma

Signet Ring Gastric Carcinoma

Fdgc

Familial Diffuse Cancer Of Stomach

Familial Diffuse Gastric Cancer

Gastric Cancer, Familial Diffuse

Gastric Cancer, Hereditary Diffuse

Hdgc

Hereditary Diffuse Cancer Of Stomach

Diffuse Gastric Cancer Syndrome

Cancer, Gastric, Diffuse

Carcinoma, Signet Ring Cell

Gastric Signet Ring Carcinoma
Enchondromatosis, Multiple, Ollier Type

Ollier Disease

Enchondromatosis

Dyschondroplasia

Osteochondromatosis

Multiple Cartilaginous Enchondroses

Multiple Enchondromatosis

Enchondromatosis With Haemangiomata

Enchondromatosis, Multiple

Kast'S Syndrome

Ollier'S Syndrome

Enchondromatosis Multiple

ENCHOM

Maffucci Disease

Olliers Disease

Hereditary Multiple Exostoses

Chondromatosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08061 MAP3K6 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus MAP3K6 VGNC VGNC:31199
Rattus norvegicus MAP3K6 RGD RGD:1304625
Macaca mulatta MAP3K6 VGNC VGNC:74496
Felis catus MAP3K6 VGNC VGNC:68160
Mus musculus MAP3K6 MGD MGI:1855691
Canis familiaris MAP3K6 VGNC VGNC:42976
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