COX7A2L - cytochrome c oxidase subunit 7A2 like Gene

中文名称：细胞色素 c 氧化酶亚基 7A2 样

种属: Homo sapiens

同用名: EB1; SCAF1; SCAFI; SIG81; COX7AR; COX7RP

关于 COX7A2L

功能概要

细胞色素 c 氧化酶 (COX) 是线粒体呼吸链的末端组分，它催化电子从还原的细胞色素 c 转移到氧气。该组分是由线粒体基因编码的 3 个催化亚基和核基因编码的多个结构亚基组成的异聚复合物。线粒体编码的亚基在电子传递中起作用，而核编码的亚基可能在复合物的调节和组装中起作用。该核基因编码的蛋白质类似于 C 末端区域亚基 VIIa 的多肽 1 和 2，也与小鼠 Sig81 蛋白质序列高度相似。该基因在所有组织中表达，并在雌激素处理后在乳腺癌细胞系中上调。该基因可能代表 COX 的一个调节亚基，并通过雌激素介导靶细胞产生更高水平的能量。已经发现该基因的几种转录变体，一些是蛋白质编码的，另一些是非蛋白质编码的。[RefSeq 提供，2016 年 1 月]

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast Cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and Others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]