2. Gene
  3. CD3G - CD3 gamma subunit of T-cell receptor complex Gene

CD3G - CD3 gamma subunit of T-cell receptor complex Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：T 细胞受体复合物的 CD3 γ 亚基

种属: Homo sapiens

同用名: T3G; IMD17; CD3GAMMA; CD3-GAMMA

基因 ID: 917 | 基因类型: protein coding

关于 CD3G

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,344,344-118,355,161 (from NCBI)

This gene has 7 transcripts (splice variants), 143 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 14.5), appendix (RPKM 7.1) and 9 other tissues.

功能概要

该基因编码的蛋白质是 CD3-γ 多肽，它与 CD3-epsilon、-delta 和 -zeta 以及 T 细胞受体 alpha/beta 和 gamma/delta 异二聚体一起形成 T 细胞受体-CD3 复合物.该复合物在将抗原识别与多种细胞内信号转导途径偶联方面起着重要作用。编码 epsilon、γ 和 delta 多肽的基因位于 11 号染色体上的同一簇中。该基因的缺陷与 T 细胞免疫缺陷有关。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]

CD3G 基因产物(1)

mRNA Protein Name
NM_000073.3 NP_000064.1 T-cell surface glycoprotein CD3 gamma chain precursor

CD3G 蛋白结构

ITAM

ITAM: Immunoreceptor tyrosine-based activation motif (157 - 175)

  • 0
  • 100
  • 182 a.a.
蛋白主名 其他名称

T-cell surface glycoprotein CD3 gamma chain

CD3g antigen, gamma polypeptide (TiT3 complex)

重组 CD3G 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77609 CD3E-CD3G Heterodimer Protein, Human (HEK293, His) P07766 (D23-E120)&P09693 (Q23-Q106) ≥95%
HY-P77611 CD3E-CD3G Heterodimer Protein, Human (HEK293, Fc) P07766 (D23-D126)&P09693 (Q23-S116) ≥95%
HY-P77613 CD3E-CD3G Heterodimer Protein, Human (Biotinylated, HEK293, Fc-Avi) P07766 (D23-D126)&P09693 (Q23-S116) ≥95%
HY-P78753 CD3 gamma Protein, Human (HEK293, Fc) P09693 (Q23-S116) ≥95%

关联疾病

疾病名称 别名
Immunodeficiency 17

IMD17

Cd3-Gamma Deficiency

Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive

Combined Immunodeficiency Due To Cd3gamma Deficiency

Immunodeficiency 17, Cd3 Gamma Deficient

Cd3gamma Deficiency

Immunodeficiency, Type 17
Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]
Immunodeficiency 18

IMD18

Cd3-Epsilon Deficiency

Immunodeficiency 18, Scid Variant

Cd3epsilon Deficiency

Immunodeficiency 18, Severe Combined Immunodeficiency Variant

Immunodeficiency, Type 18
Immunodeficiency 19

IMD19

Cd3-Delta Deficiency

Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive

Cd3delta Deficiency

Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive

Immunodeficiency 19, Severe Combined

Cd3d

Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive

T Cell-Negative, B Cell-Positive, Nk Cell-Positive Scid

T Cell-Negative, B Cell-Positive, Nk Cell-Positive Severe Combined Immunodeficiency

Immunodeficiency, Type 19
Cd3zeta Deficiency
Lymphopenia

Lymphocytopenia
Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia
Granulomatous Disease, Chronic, Autosomal Recessive, 3

CGD3

Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii

Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii

Granulomatous Disease, Chronic, Due To Ncf4 Deficiency

Chronic Granulomatous Disease 3, Autosomal Recessive

Autosomal Recessive Chronic Granulomatous Disease 3

Autosomal Recessive Cytochrome B-Positive Cgd Type Iii

Cdg3

Chronic Granulomatous Disease Due To Ncf4 Deficiency

Cgd Autosomal Recessive Cytochrome B-Positive Type Iii

Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii

Granulomatous Disease Chronic Due To Ncf4 Deficiency

Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3
Omenn Syndrome

Histiocytic Medullary Reticulosis

Severe Combined Immunodeficiency With Hypereosinophilia

Combined Immunodeficiency With Hypereosinophilia

Reticuloendotheliosis, Familial, With Eosinophilia

Reticuloendotheliosis Familial With Eosinophilia

Familial Reticuloendotheliosis

Omenn'S Syndrome

OS

Malignant Histiocytosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02244 CD3G Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CD3G MGD MGI:88333
Canis familiaris CD3G VGNC VGNC:38957
Rattus norvegicus CD3G RGD RGD:1307718
Felis catus CD3G VGNC VGNC:60617
Bos taurus CD3G VGNC VGNC:27031
Macaca mulatta CD3G VGNC VGNC:100904
Macaca fascicularis CD3G NCBI
Others CD3G NCBI
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