2. Gene
  3. CHMP4C - charged multivesicular body protein 4C Gene

CHMP4C - charged multivesicular body protein 4C Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：带电多泡体蛋白 4C

种属: Homo sapiens

同用名: Shax3; SNF7-3; VPS32C

基因 ID: 92421 | 基因类型: protein coding

关于 CHMP4C

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:81,732,448-81,759,515 (from NCBI)

This gene has 1 transcript (splice variant), 193 orthologues and 4 paralogues. Broad expression in duodenum (RPKM 19.0), small intestine (RPKM 14.8) and 19 other tissues.

功能概要

CHMP4C 属于染色质修饰蛋白/带电多泡体蛋白 (CHMP) 家族。这些蛋白质是 ESCRT-III (运输 III 所需的内体分选复合物) 的组分，ESCRT-III 是一种参与表面受体蛋白降解和内吞多泡体 (MVB) 形成的复合物。一些 CHMP 具有细胞核和细胞质/囊泡分布，其中一种 CHMP，CHMP1A (MIM 164010) ，是 MVB 形成和细胞周期进程调节所必需的 (Tsang 等人，2006 [PubMed 16730941]) 。[OMIM，2008 年 3 月]

CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface Receptor Proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

CHMP4C 基因产物(1)

mRNA Protein Name
NM_152284.4 NP_689497.1 charged multivesicular body protein 4c
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14505570 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
14505570 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in abscission IMP
IMP: 通过突变表型推断
22422861 GOA
involved in autophagosome maturation IMP
IMP: 通过突变表型推断
17984323 GOA
involved in autophagy IMP
IMP: 通过突变表型推断
17984323 GOA
involved in late endosome to lysosome transport IMP
IMP: 通过突变表型推断
17984323 GOA
involved in midbody abscission IMP
IMP: 通过突变表型推断
20616062 GOA
involved in mitotic cytokinesis checkpoint signaling IMP
IMP: 通过突变表型推断
22422861 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: 通过突变表型推断
20616062 GOA
involved in multivesicular body sorting pathway IDA
IDA: 通过直接分析推断
16554368 GOA
involved in negative regulation of cytokinesis IMP
IMP: 通过突变表型推断
22422861 GOA
involved in nuclear membrane reassembly IMP
IMP: 通过突变表型推断
26040713 GOA
involved in nucleus organization IMP
IMP: 通过突变表型推断
20616062 GOA
involved in plasma membrane repair IDA
IDA: 通过直接分析推断
24482116 GOA
involved in regulation of centrosome duplication IMP
IMP: 通过突变表型推断
20616062 GOA
involved in regulation of mitotic spindle assembly IMP
IMP: 通过突变表型推断
20616062 GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IDA
IDA: 通过直接分析推断
17984323 GOA
involved in ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway IMP
IMP: 通过突变表型推断
22547407 GOA
involved in viral budding from plasma membrane IDA
IDA: 通过直接分析推断
24878737 GOA
involved in viral budding from plasma membrane IMP
IMP: 通过突变表型推断
14505570 GOA
involved in viral budding via host ESCRT complex IDA
IDA: 通过直接分析推断
24878737 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Flemming body IDA
IDA: 通过直接分析推断
22422861 GOA
located in amphisome membrane IDA
IDA: 通过直接分析推断
17984323 GOA
located in autophagosome membrane IDA
IDA: 通过直接分析推断
17984323 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
26040712 GOA
located in kinetochore microtubule IDA
IDA: 通过直接分析推断
26040712 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
17984323 GOA
located in midbody IDA
IDA: 通过直接分析推断
22724069 GOA
located in multivesicular body membrane IDA
IDA: 通过直接分析推断
16554368 GOA
part of nuclear pore IDA
IDA: 通过直接分析推断
26040713 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
24878737 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CHMP4C 蛋白结构

Snf7

Snf7: Snf7 (24 - 192)

  • 0
  • 100
  • 200
  • 233 a.a.
蛋白主名 其他名称

charged multivesicular body protein 4c

SNF7 homolog associated with Alix 3

CHMP4C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CHMP4C Q96CF2 PDCD6IP Homo sapiens Q8WUM4
Y2H
21988832
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02645 CHMP4C Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CHMP4C VGNC VGNC:71143
Canis familiaris CHMP4C VGNC VGNC:39224
Bos taurus CHMP4C VGNC VGNC:27303
Felis catus CHMP4C VGNC VGNC:60864
Rattus norvegicus CHMP4C RGD RGD:1564543
Mus musculus CHMP4C MGD MGI:1913621
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