1. Gene
  2. CPNE6 - copine 6 Gene

CPNE6 - copine 6 Gene

中文名称:应对 6

种属: Homo sapiens

基因 ID: 9362 | 基因类型: protein coding

关于 CPNE6

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:24,070,949-24,078,087 (from NCBI)

This gene has 20 transcripts (splice variants), 1 gene allele, 193 orthologues and 8 paralogues. Biased expression in brain (RPKM 23.5), small intestine (RPKM 2.5) and 3 other tissues.

功能概要

这个基因编码了一个科品家族的成员。这个家族的成员是钙依赖性磷脂结合蛋白,具有 C2 结构域,两个钙和磷脂结合结构域。通过它们的结构域结构和脂质结合能力,这些蛋白质可能在膜运输中发挥作用。这种蛋白质被认为是大脑特异性的,具有两个 N 末端 C2 结构域和一个 von Willebrand 因子 A 结构域的结构域。它可能在突触可塑性中起作用。[RefSeq 提供,2013 年 7 月]

This gene encodes a member of the copine family. Members of this family are calcium-dependent, phospholipid-binding proteins with C2 domains, two calcium- and phospholipid-binding domains. Through their domain structure and lipid binding capabilities, these proteins may play a role in membrane trafficking. This protein is thought to be brain-specific and has a domain structure of two N-terminal C2 domains and one von Willebrand factor A domain. It may have a role in synaptic plasticity. [provided by RefSeq, Jul 2013]

CPNE6 基因产物(5)

mRNA Protein Name
NM_001280558.2 NP_001267487.1 copine-6 isoform 1
NM_001385056.1 NP_001371985.1 copine-6 isoform 2
NM_001385057.1 NP_001371986.1 copine-6 isoform 2
NM_001385058.1 NP_001371987.1 copine-6 isoform 2
NM_006032.4 NP_006023.1 copine-6 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of dendrite extension IDA
IDA: 通过直接分析推断
23999003 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CPNE6 蛋白结构

C2

C2: C2 domain (26 - 109)

C2

C2: C2 domain (158 - 242)

Copine

Copine: Copine (325 - 472)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 557 a.a.
蛋白主名 其他名称

copine-6

N-copine

CPNE6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CPNE6 O95741 MEOX2 Homo sapiens P50222 25416956
种属内
CPNE6 O95741 MEOX2 Homo sapiens P50222 25416956
种属内
CPNE6 O95741 MEOX2 Homo sapiens P50222 25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Vertebral Artery Occlusion

Occlusion And Stenosis Of Vertebral Artery

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CPNE6 VGNC VGNC:71468
Felis catus CPNE6 VGNC VGNC:61133
Rattus norvegicus CPNE6 RGD RGD:1583895
Bos taurus CPNE6 VGNC VGNC:27662
Canis familiaris CPNE6 VGNC VGNC:39565
Mus musculus CPNE6 MGD MGI:1334445