1. Gene
  2. LIPG - lipase G, endothelial type Gene

LIPG - lipase G, endothelial type Gene

中文名称:脂肪酶 G,内皮型

种属: Homo sapiens

同用名: EL; EDL; PRO719

基因 ID: 9388 | 基因类型: protein coding

关于 LIPG

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:49,561,479-49,599,185 (from NCBI)

This gene has 7 transcripts (splice variants), 217 orthologues and 9 paralogues. Biased expression in thyroid (RPKM 109.5), placenta (RPKM 50.3) and 3 other tissues.

功能概要

该基因编码的蛋白质具有很强的磷脂酶活性,可能参与脂蛋白代谢和血管生物学。该蛋白质因其序列和特征性盖区而被指定为 TG 脂肪酶家族的成员,该盖区为 TG 脂肪酶家族的酶提供底物特异性。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene has substantial Phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG Lipase family by its sequence and characteristic lid region which provides substrate specificity for Enzymes of the TG Lipase family. [provided by RefSeq, Jul 2008]

LIPG 基因产物(2)

mRNA Protein Name
NM_001308006.2 NP_001294935.1 endothelial lipase isoform 2 precursor
NM_006033.4 NP_006024.1 endothelial lipase isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phospholipase A1 activity IDA
IDA: 通过直接分析推断
10318835 GOA
enables phospholipase activity IDA
IDA: 通过直接分析推断
10192396 GOA
enables triacylglycerol lipase activity IDA
IDA: 通过直接分析推断
12032167 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cholesterol homeostasis IMP
IMP: 通过突变表型推断
19136670 GOA
involved in high-density lipoprotein particle remodeling IMP
IMP: 通过突变表型推断
19136670 GOA
involved in phospholipid homeostasis IMP
IMP: 通过突变表型推断
19136670 GOA
involved in positive regulation of cholesterol transport IDA
IDA: 通过直接分析推断
19136670 GOA
involved in positive regulation of high-density lipoprotein particle clearance IMP
IMP: 通过突变表型推断
19136670 GOA
involved in reverse cholesterol transport IMP
IMP: 通过突变表型推断
19136670 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
23918928 GOA
located in cell surface IDA
IDA: 通过直接分析推断
23918928 GOA
located in early endosome IDA
IDA: 通过直接分析推断
23918928 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
10192396 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LIPG 蛋白结构

Lipase

Lipase: Lipase (39 - 344)

PLAT

PLAT: PLAT/LH2 domain (349 - 481)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500 a.a.
蛋白主名 其他名称

endothelial lipase

endothelial cell-derived lipase

关联疾病

疾病名称 别名
Hypobetalipoproteinemia, Familial, 2

Familial Hypobetalipoproteinemia 2

FHBL2

Hypolipidemia, Familial, Combined

Combined Familial Hypolipidemia

Combined Hypobetalipoproteinemia Familial

Hypobetalipoproteinemia, Familial, Type 2

Lipase Deficiency, Combined

Lipoprotein Lipase Deficiency With Hepatic Triglyceride Lipase Deficiency

Lpl And Htgl Deficiency

Lpl And Hl Deficiency

Familial Lipase Maturation Factor 1 Deficiency

Lipase Deficiency Combined

Combined Lipase Deficiency

Familial Lmf1 Deficiency

CLD

Lipid Metabolism Disorder

Dyslipidemia

Disorder Of Fatty Acid Metabolism

Lipid Metabolism Disorders

Fatty Acid Metabolism Disorder

Disorder Of Lipid Metabolism

Abnormality Of Lipid Metabolism

Lipid Metabolism, Inborn Errors

Dyslipidemias

Disorders Of Lipid Metabolism

Congenital Disorders Of Lipid Metabolism

Inherited Disorders Of Lipid Metabolism

Hyperlipoproteinemia, Type I

Lipoprotein Lipase Deficiency

Familial Chylomicronemia Syndrome

Lpl Deficiency

Hyperchylomicronemia, Familial

Hyperlipemia, Idiopathic, Burger-Grutz Type

Hyperlipemia, Essential Familial

Lipase D Deficiency

Lipd Deficiency

Hyperlipoproteinemia, Type Ia

Chylomicronemia, Familial

High Density Lipoprotein Cholesterol Level Qtl 11

Hyperlipoproteinemia Type 1

Hyperlipoproteinemia 1

HLPP1

Lipoprotein Lipase

Hyperlipoproteinemia Type I

Familial Hyperchylomicronemia Syndrome

Atherosclerosis Susceptibility

Atherosclerosis

Atherosclerosis, Susceptibility To

ATHS

Atherogenic Lipoprotein Phenotype

Alp

Arteriosclerosis

Hypoalphalipoproteinemia, Primary, 1

Familial Hdl Deficiency

Fha

High Density Lipoprotein Deficiency

Familial Hypoalphalipoproteinemia

Hypoalphalipoproteinemia, Familial

Hdld

Fhd

Hdl Deficiency, Type 2

Primary Hypoalphalipoproteinemia 1

Hdl Cholesterol, Low Serum

Hdlc

Hdl Deficiency, Familial, 1

Hypoalphalipoproteinemia, Primary

Low Serum Hdl Cholesterol

Primary Hypoalphalipoproteinemia

FHA1

Hdld2

High Density Lipoprotein Deficiency 2

Hypoalphalipoproteinemias

Apolipoprotein A-I Deficiency

Hypobetalipoproteinemia, Familial, 1

Hypobetalipoproteinemia

Familial Hypobetalipoproteinemia 1

Familial Hypobetalipoproteinemia

FHBL1

Hypobetalipoproteinemia, Familial

Fhbl

Acanthocytosis With Hypobetalipoproteinemia

Hypobetalipoproteinemias

Hypobetalipoproteinemia, Normotriglyceridemic

Hypo-Beta-Lipoproteinemia

Hypobetalipoprotéinemia, Familial

Normotriglyceridemic Hypobetalipoproteinemia

Hypobetalipoproteinemia, Familial, Type 1

Hypolipoproteinemia

Hypolipoproteinaemia

Lipoprotein Deficiencies

Lipoprotein Disorder

Hypolipoproteinemias

Lipoprotein

Lipoprotein Deficiency

Hypolipidaemia

Lipoprotein Deficiency Disorder

High-Density Lipoid Deficiency

High-Density Lipoprotein Deficiency

Dyslipidaemia, Depressed Hdl Cholesterol

Familial Lipoprotein Lipase Deficiency

Familial Lpl Deficiency

Familial Hyperchylomicronemia

Hyperlipoproteinemia Type I

Familial Hyperlipoproteinemia Type I

Hyperchylomicronemia

Burger-Grutz Syndrome

Endogenous Hypertriglyceridaemia

Familial Fat-Induced Hypertriglyceridemia

Lipd Deficiency

Lpl Deficiency

Lipase D Deficiency

Lipoprotein Lipase Deficiency, Familial

Familial Chylomicronemia Syndrome

Fredrickson Type I Hyperlipoproteinemia

Fredrickson Type I Lipaemia

Hypercholesterinaemic Xanthomatosis

Mixed Hyperglyceridemia

Lipoprotein Lipase Deficiency

Type I Hyperlipoproteinemia

Hyperlipoproteinemia Type Ia

Familial Hyperlipo-Proteinemia Type 1

Cardiovascular System Disease

Abnormality Of The Cardiovascular System

Cardiovascular Disease

Disease Of Subdivision Of Hemolymphoid System

Disorder Of Cardiovascular System

Cardiovascular Diseases

Aortic Atherosclerosis

Atherosclerosis Of Aorta

Aorta Atheroma

Aorta Calcification

Aorta Arteriosclerosis

Aortic Degeneration

Aortic Calcification

Aortic Atheroma

Aortic Arteriosclerotic Disease

Aortic Arteriosclerosis

Aorta Sclerosis

Aorta Degeneration

Atheromatous Aortic

Calcified Aortic Stenosis

Atheromatous Aorta

Arteriosclerotic Aortitis

Arteriosclerotic Aortic Stenosis

Arteriosclerotic Aorta Disease

Aortic Sclerosis

Tangier Disease

Analphalipoproteinemia

High Density Lipoprotein Deficiency, Tangier Type

TGD

High Density Lipoprotein Deficiency, Type 1

Hdldt1

Familial High Density Lipoprotein Deficiency

A-Alphalipoprotein Neuropathy

Alpha High Density Lipoprotein Deficiency Disease

Cholesterol Thesaurismosis

Familial High Density Lipoprotein Deficiency Disease

Hdl Lipoprotein Deficiency Disease

Tangier Disease Neuropathy

Familial Alpha-Lipoprotein Deficiency

Familial High-Density Lipoprotein Deficiency 1

Primary Hypoalphalipoproteinemia 1

Analphalipo-Proteinemia

Familial Hypoalphalipo-Proteinemia

Familial Hypoalphalipoproteinemia

Lipoprotein Deficiency Disease, Hdl, Familial

Tangier Hereditary Neuropathy

Atp-Binding Cassette Transporter A1 Deficiency

Hdld1

High Density Lipoprotein Deficiency 1

Tangier Disease, Variant

Hypoalphalipoproteinemia, Familial

Familial Hdl Deficiency

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia

Familial Hyperbetalipoproteinaemia

Familial Hypercholesteremia

Fredrickson Type Iia Hyperlipoproteinemia

Fredrickson Type Iia Lipidaemia

Hyperbetalipoproteinemia

Type Ii Hyperlipidemia

Familial Hypercholesterolæmia

Familial Hypercholesterolaemia

Fh

Hypercholesterolemia Familial

Hyperlipoproteinemia Type Ii

Hypercholesterolemia, Familial

Diabetes Mellitus

Diabetes

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus LIPG VGNC VGNC:109399
Mus musculus LIPG MGD MGI:1341803
Rattus norvegicus LIPG RGD RGD:1310740
Canis familiaris LIPG VGNC VGNC:53618
Felis catus LIPG VGNC VGNC:68059
Macaca mulatta LIPG VGNC VGNC:74423