1. Gene
  2. CGB7 - chorionic gonadotropin subunit beta 7 Gene

CGB7 - chorionic gonadotropin subunit beta 7 Gene

中文名称:绒毛膜促性腺激素亚基β7

种属: Homo sapiens

同用名: CGB6; CG-beta-a

基因 ID: 94027 | 基因类型: protein coding

关于 CGB7

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,054,274-49,057,749 (from NCBI)

This gene has 4 transcripts (splice variants), 37 orthologues and 9 paralogues. Biased expression in placenta (RPKM 5.5), skin (RPKM 1.3) and 1 other tissue.

功能概要

该基因是糖蛋白激素 β 链家族的成员,编码绒毛膜促性腺激素 (CG) 的 β 7 亚基。糖蛋白激素是异二聚体,由一个共同的α亚基和一个独特的β亚基组成,具有生物特异性。 CG 由胎盘的滋养层细胞产生,可刺激卵巢合成维持妊娠所必需的类固醇。 CG 的 β 亚基由 6 个基因编码,这些基因在染色体 19q13.3 上串联和倒置成对排列,并与促黄体激素 β 亚基基因相邻。[RefSeq 提供,2008 年 7 月]

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic gonadotropin (CG). Glycoprotein Hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the Steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

CGB7 基因产物(2)

mRNA Protein Name
NM_001385261.1 NP_001372190.1 choriogonadotropin subunit beta 7 precursor
NM_033142.2 NP_149133.1 choriogonadotropin subunit beta 7 precursor

CGB7 蛋白结构

Cys_knot

Cys_knot: Cystine-knot domain (27 - 130)

  • 0
  • 100
  • 165 a.a.
蛋白主名 其他名称

choriogonadotropin subunit beta 7

chorionic gonadotropin beta 7 subunit

重组 CGB7 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76820 CGB7 Protein, Human (sf9, His) P0DN87-1 (S21-Q165) ≥95%

CGB7 抗体

目录号 产品名 应用 反应物种
HY-P86051 hCG beta Antibody (YA5743) IHC-P, ICC/IF, ELISA Human

关联疾病

疾病名称 别名
Ectopic Pregnancy

Eccyesis

Pregnancy Ectopic

Pregnancy, Ectopic

Ectopic Pregnancies

Extrauterine Gestation Or Pregnancy

Extrauterine Pregnancy

Ep - [Ectopic Pregnancy]

Ectopic Mole

Aborted Ectopic Pregnancy

Ruptured Ectopic Pregnancy

Choriocarcinoma

Chorioepithelioma

Chromosomal Triplication

Trisomy

Seminoma

Seminoma, Pure

Teratoma

Teratomas

Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21

Mixed Ductal-Endocrine Carcinoma
Leydig Cell Hypoplasia Type Ii

46,Xy Disorder Of Sex Developement Due To Partial Lh Receptor Inactivation

46,Xy Disorder Of Sex Developement Due To Partial Lh Resistance

46,Xy Disorder Of Sex Developement Due To Partial Luteinizing Hormone Resistance

46,Xy Dsd Due To Partial Lh Receptor Inactivation

46,Xy Dsd Due To Partial Lh Resistance

46,Xy Dsd Due To Partial Luteinizing Hormone Resistance

Leydig Cell Hypoplasia Due To Partial Lh Receptor Inactivation

Leydig Cell Hypoplasia Due To Partial Lh Resistance

Leydig Cell Hypoplasia Due To Partial Luteinizing Hormone Receptor Inactivation

Leydig Cell Hypoplasia Due To Partial Luteinizing Hormone Resistance

Leydig Cell Hypoplasia, Type Ii

Patellofemoral Pain Syndrome
Placenta Disease

Placenta Diseases

Placenta Disorder

Pregnancy Complications

Placenta Disorders

Germinoma
Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia

Smith-Lemli-Opitz Syndrome

SLOS

Rsh Syndrome

7-Dehydrocholesterol Reductase Deficiency

Slo Syndrome

Rutledge Lethal Multiple Congenital Anomaly Syndrome

Lethal Acrodysgenital Syndrome

Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobar Lung

Smith-Opitz-Inborn Syndrome

Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobular Lung

Smith Lemli Opitz Syndrome

Smith-Lemli-Opitz Syndrome, Type Ii

Cryptococcosis

Cryptococcus Neoformans Infection

Torulosis

Busse-Buschke'S Disease

Cryptococcal Infection

European Cryptococcosis

Torula

Infection By Cryptococcus Neoformans

Cryptococcosis Infection

European Blastomycosis

European Blastomycotic Infection

European Blastomycoses Infection

Torula Histolytica Infection

Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CGB7 MGD MGI:96782