SELENOF - selenoprotein F Gene

中文名称：硒蛋白 F

种属: Homo sapiens

同用名: SEP15

关于 SELENOF

功能概要

该基因编码的蛋白质属于 SEP15/硒蛋白 M 家族。这种蛋白质的确切功能尚不清楚；然而，已发现它与 UDP-葡萄糖：糖蛋白葡糖基转移酶 (UGTR) 相关，UGTR 是一种内质网 (ER) 常驻蛋白，参与蛋白质折叠的质量控制。与 UGTR 的结合将这种蛋白质保留在 ER 中，它可能在蛋白质折叠中发挥作用。它也被认为在癌症病因学中起作用。这种蛋白质是一种硒蛋白，含有稀有氨基酸硒代半胱氨酸 (Sec) 。 Sec 由 UGA 密码子编码，通常表示翻译终止。硒蛋白 mRNA 的 3' UTR 包含一个保守的茎环结构，称为 Sec 插入序列 (SECIS) 元件，这是将 UGA 识别为 Sec 密码子而不是终止信号所必需的。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2016 年 11 月]

The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in Cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016]