NAPSA - napsin A aspartic peptidase Gene

中文名称：napsin A 天冬氨酸肽酶

种属: Homo sapiens

同用名: KAP; Kdap; NAP1; NAPA; SNAPA

基因 ID: 9476 | 基因类型: protein coding

关于 NAPSA

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,358,477-50,365,639 (from NCBI)

This gene has 7 transcripts (splice variants), 119 orthologues and 9 paralogues. Restricted expression toward lung (RPKM 393.9).

功能概要

该基因编码天冬氨酸蛋白酶肽酶 A1 家族的一个成员。编码的前原蛋白经过蛋白水解处理，生成激活肽和成熟蛋白酶。天冬氨酸蛋白酶的活化肽起到蛋白酶活性位点抑制剂的作用。这些肽段或前体部分被认为对于正确折叠、靶向和控制天冬氨酸蛋白酶酶原的激活很重要。编码的蛋白酶可能在肺中肺表面活性蛋白 B 的蛋白水解过程中发挥作用，并可能在肾近端小管中的蛋白质分解代谢中发挥作用。该基因已被描述为肺腺癌和肾细胞癌的标志物。[RefSeq 提供，2016 年 2 月]

This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016]

NAPSA 基因产物(1)

mRNA	Protein	Name
NM_004851.3	NP_004842.1	napsin-A preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables endopeptidase activity	IDA IDA: 通过直接分析推断	14766755	GOA
enables peptidase activity	IDA IDA: 通过直接分析推断	18216060	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in membrane protein proteolysis	IDA IDA: 通过直接分析推断	14766755	GOA
involved in surfactant homeostasis	IDA IDA: 通过直接分析推断	18216060	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in alveolar lamellar body	IDA IDA: 通过直接分析推断	18216060	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	18216060	GOA
located in lysosome	IDA IDA: 通过直接分析推断	14766755	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NAPSA 蛋白结构

Asp

0
100
200
300
420 a.a.

蛋白主名

其他名称

napsin-A

ASP4

NAPSA 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NAPSA	O96009	LCE1B	Homo sapiens	Q5T7P3	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

NAPSA 抗体

目录号	产品名	应用	反应物种
HY-P81885	Napsin A Antibody (YA1630)	WB, IHC-P, IP	Human
HY-P83883	Napsin A Antibody (YA3580)	WB, IHC-P, ELISA	Human, Rat
HY-P85849	Napsin A Antibody (YA5541)	IHC-P, WB, ICC/IF, ELISA	Human
HY-P86021	Napsin A Antibody (YA5713)	IHC-P, ICC/IF, ELISA	Human

关联疾病

疾病名称

别名

Ovarian Clear Cell Adenofibroma

Adenocarcinoma

Adenocarcinomas	Adenoacanthoma Of Unspecified Site
Adenocarcinoid Of Unspecified Site	Adenocarcinoid Tumour Of Unspecified Site
Adenocarcinoma And Carcinoid Combined Of Unspecified Site	Adenocarcinoma Nos

Endometrial Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of Endometrium

Solid Adenocarcinoma With Mucin Production

Cervical Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of The Cervix Uteri

Cervical Endometrioid Adenocarcinoma

Endometrioid Carcinoma Of The Cervix Uteri

Ureter Squamous Cell Carcinoma

Ureteral Epidermoid Carcinoma

Pleomorphic Carcinoma

Krukenberg Carcinoma

Krukenberg Tumor	Krukenberg Neoplasm
Krukenberg'S Tumor

Bladder Clear Cell Adenocarcinoma

Bladder Mesonephric Adenocarcinoma

Clear Cell Adenocarcinoma Of Bladder

Lung Giant Cell Carcinoma

Carcinoma, Giant Cell	Giant Cell Carcinoma
Giant Cell Lung Carcinoma	Carcinoma Giant Cell
Giant Cell Carcinoma Of Lung

Clear Cell Adenofibroma

Cystadenofibroma

Papillary Adenoma

Glandular Papilloma

Adenoma

Lung Combined Type Small Cell Carcinoma

Combined Small Cell Carcinoma Of The Lung

Combined Type Small Cell Carcinoma Of Lung

Lung Large Cell Carcinoma

Large Cell Carcinoma Of Lung	Large Cell Lung Carcinoma
Large Cell Lung Cancer

Non-Invasive Bladder Urothelial Carcinoma

Stage 0 Bladder Urothelial Carcinoma

Large Cell Neuroendocrine Carcinoma

Papillary Adenofibroma

Bronchus Adenoma

Bronchial Adenoma

Adenoma Of The Bronchus

Lung Sarcomatoid Carcinoma

Sarcomatoid Carcinoma Of The Lung

Pulmonary Sarcomatoid Carcinoma

Bladder Adenocarcinoma

Adenocarcinoma Of Bladder	Adenocarcinoma Of The Urinary Bladder
Bladder Adenocarcinoma, Not Otherwise Specified	Adenocarcinoma Bladder

Cervical Mucinous Adenocarcinoma

Mucinous Adenocarcinoma

Mucin-Producing Adenocarcinoma	Mucin-Secreting Adenocarcinoma
Mucin-Secreting Carcinoma	Mucous Carcinoma
Pseudomyxoma Peritonei With Unknown Primary Site	Adenocarcinoma, Mucinous

Lung Cancer Susceptibility 3

Lung Adenocarcinoma	Adenocarcinoma Of Lung
LNCR3	Adenocarcinoma Of Lung, Susceptibility To
Bronchogenic Lung Adenocarcinoma	Nonsmall Cell Adenocarcinoma
Adenocarcinoma Lung	Lung Adenocarcinomas
Non-Small Cell Adenocarcinoma

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Pulmonary Large Cell Neuroendocrine Carcinoma

Large Cell Lung Neuroendocrine Carcinoma

Mucinous Lung Adenocarcinoma

Trigonitis

Bladder Trigonitis

Pseudomembranous Trigonitis

Ovarian Endodermal Sinus Tumor

Endodermal Sinus Tumor Of Ovary	Ovarian Yolk Sac Tumor
Endodermal Sinus Tumour Of Ovary	Ovarian Endodermal Sinus Tumour
Ovarian Yolk Sac Tumour

Respiratory System Benign Neoplasm

Bronchial Benign Neoplasm

Bronchus Neoplasm	Neoplasm Of Bronchus
Bronchial Neoplasms	Bronchial Neoplasm

Adenofibroma

Adenocarcinoma In Situ

Lung Clear Cell Carcinoma

Parotid Gland Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Parotid Gland

Small Cell Carcinoma

Small Cell Carcinoma, Intermediate Cell	Intermediate Cell Small Cell Carcinoma
Small Cell Carcinoma - Intermediate Cell	Small Cell Carcinoma Of Lung
Carcinoma, Small Cell

Ovarian Primitive Germ Cell Tumor

Basaloid Squamous Cell Carcinoma

Basaloid Carcinoma

Clear Cell Adenocarcinoma

Mesonephroma	Water-Clear Cell Adenocarcinoma
Adenocarcinoma, Clear Cell	Malignant Mesonephroma
Mesonephroid Clear Cell Carcinoma	Mesonephroma, Malignant
Water-Clear Cell Carcinoma	Wolffian Duct Neoplasm
Adenocarcinoma Clear Cell	Mesonephric Tumor

Keratinizing Squamous Cell Carcinoma

Squamous Cell Carcinoma, Keratinizing

Keratinizing Epidermoid Carcinoma

Papillary Adenocarcinoma

Infiltrating And Papillary Adenocarcinoma	Infiltrating Papillary Adenocarcinoma
Adenocarcinoma Papillary	Adenocarcinoma, Papillary

Ovarian Clear Cell Carcinoma

Clear-Cell Ovarian Carcinoma

Large Cell Carcinoma

Carcinoma, Large Cell

Carcinoma Large Cell

Esophageal Neuroendocrine Tumor

Esophageal Neuroendocrine Tumour	Neuroendocrine Tumor Of Esophagus
Neuroendocrine Tumour Of Oesophagus

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Serous Cystadenocarcinoma

Serous Adenocarcinoma	Cystadenocarcinoma, Serous
Serous Carcinoma	Cystadenocarcinoma Serous

直系同源

种属	基因名	来源	基因 ID
Felis catus	NAPSA	VGNC	VGNC:63723
Bos taurus	NAPSA	VGNC	VGNC:31886
Mus musculus	NAPSA	MGD	MGI:109365
Canis familiaris	NAPSA	VGNC	VGNC:43624
Rattus norvegicus	NAPSA	RGD	RGD:61940