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  2. NPEPPS - aminopeptidase puromycin sensitive Gene

NPEPPS - aminopeptidase puromycin sensitive Gene

中文名称:氨肽酶嘌呤霉素敏感

种属: Homo sapiens

同用名: PSA; AAP-S; MP100

基因 ID: 9520 | 基因类型: protein coding

关于 NPEPPS

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,522,933-47,623,276 (from NCBI)

This gene has 41 transcripts (splice variants), 224 orthologues and 11 paralogues. Ubiquitous expression in esophagus (RPKM 43.2), brain (RPKM 28.6) and 25 other tissues.

功能概要

该基因编码嘌呤霉素敏感性氨肽酶,一种锌金属肽酶,可从其底物的 N 末端水解氨基酸。该蛋白质已定位于细胞质和细胞膜。这种酶可降解大脑中的脑啡肽,对小鼠的研究表明它参与调节细胞周期的蛋白水解事件。[RefSeq 提供,2008 年 7 月]

This gene encodes the puromycin-sensitive Aminopeptidase, a zinc metallopeptidase which hydrolyzes Amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]

NPEPPS 基因产物(3)

mRNA Protein Name
NM_001330257.2 NP_001317186.1 puromycin-sensitive aminopeptidase isoform 2
NM_001411130.1 NP_001398059.1 puromycin-sensitive aminopeptidase isoform 3
NM_006310.4 NP_006301.3 puromycin-sensitive aminopeptidase isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aminopeptidase activity EXP
EXP: 通过实验结果推断
9668046 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hypoxia IDA
IDA: 通过直接分析推断
21056661 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NPEPPS 蛋白结构

Peptidase_M1

Peptidase_M1: Peptidase family M1 domain (53 - 441)

ERAP1_C

ERAP1_C: ERAP1-like C-terminal domain (578 - 891)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 919 a.a.
蛋白主名 其他名称

puromycin-sensitive aminopeptidase

cytosol alanyl aminopeptidase

关联疾病

疾病名称 别名
Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NPEPPS RGD RGD:619962
Mus musculus NPEPPS MGD MGI:1101358
Felis catus NPEPPS VGNC VGNC:97532
Bos taurus NPEPPS VGNC VGNC:57146
Canis familiaris NPEPPS VGNC VGNC:97210
Macaca mulatta NPEPPS VGNC VGNC:97796