GCC2 - GRIP and coiled-coil domain containing 2 Gene

中文名称：含 GRIP 和卷曲卷曲结构域 2

种属: Homo sapiens

同用名: REN53; GCC185; RANBP2L4

基因 ID: 9648 | 基因类型: protein coding

关于 GCC2

Cytogenetic location: 2q12.3 Genomic coordinates (GRCh38): 2:108,449,206-108,509,415 (from NCBI)

This gene has 25 transcripts (splice variants), 192 orthologues and 3 paralogues. Ubiquitous expression in gall bladder (RPKM 11.9), thyroid (RPKM 11.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种位于跨高尔基体网络的外周膜蛋白。它对 brefeldin A 敏感。这种编码的蛋白质包含一个 GRIP 结构域，该结构域被认为可用于靶向。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 7 月]

The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

GCC2 基因产物(2)

mRNA	Protein	Name
NM_001410194.1	NP_001397123.1	GRIP and coiled-coil domain-containing protein 2 isoform 2
NM_181453.4	NP_852118.2	GRIP and coiled-coil domain-containing protein 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	18243103	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16885419	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Golgi ribbon formation	IMP IMP: 通过突变表型推断	16885419	GOA
NOT involved in Golgi to plasma membrane protein transport	IMP IMP: 通过突变表型推断	16885419	GOA
involved in late endosome to Golgi transport	IMP IMP: 通过突变表型推断	16885419	GOA
involved in microtubule anchoring	IMP IMP: 通过突变表型推断	17543864	GOA
involved in microtubule organizing center organization	IMP IMP: 通过突变表型推断	17543864	GOA
involved in protein localization to Golgi apparatus	IMP IMP: 通过突变表型推断	16885419	GOA
involved in protein targeting to lysosome	IMP IMP: 通过突变表型推断	16885419	GOA
involved in recycling endosome to Golgi transport	IMP IMP: 通过突变表型推断	17488291	GOA
involved in regulation of protein exit from endoplasmic reticulum	IMP IMP: 通过突变表型推断	17488291	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: 通过突变表型推断	17488291	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	18243103	GOA
located in trans-Golgi network	IDA IDA: 通过直接分析推断	16885419	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GCC2 蛋白结构

GRIP

0
300
600
900
1200
1500
1684 a.a.

蛋白主名

其他名称

GRIP and coiled-coil domain-containing protein 2

185 kDa Golgi coiled-coil protein

GCC2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GCC2	Q8IWJ2	RAB6A	Homo sapiens	P20340	Affinity Chrom	18243103
种属内	GCC2	Q8IWJ2	RAB6A	Homo sapiens	P20340	ITC	18243103
种属内	GCC2	Q8IWJ2	RAB9A	Canis familiaris	P24408	Affinity Chrom	18243103
种属内	GCC2	Q8IWJ2	RAB9A	Canis familiaris	P24408	ITC	18243103

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Charcot-Marie-Tooth Disease, Axonal, Type 2z

CMT2Z	Charcot-Marie-Tooth Disease Axonal Type 2z
Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2z	Charcot-Marie-Tooth Neuropathy, Type 2z
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2z	Charcot-Marie-Tooth Neuropathy Type 2z
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2z	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Morc2 Mutation
Charcot-Marie-Tooth Disease 2z	Charcot-Marie-Tooth Disease, Type 2z

Bladder Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Bladder	Epidermoid Carcinoma Of The Urinary Bladder
Carcinoma Squamous Cell Bladder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05320	GCC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	GCC2	VGNC	VGNC:41140
Bos taurus	GCC2	VGNC	VGNC:29281
Felis catus	GCC2	VGNC	VGNC:62488
Mus musculus	GCC2	MGD	MGI:1917547
Macaca mulatta	GCC2	VGNC	VGNC:72765
Rattus norvegicus	GCC2	RGD	RGD:1305732

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