1. Gene
  2. SOCS5 - suppressor of cytokine signaling 5 Gene

SOCS5 - suppressor of cytokine signaling 5 Gene

中文名称:细胞因子信号传导抑制因子 5

种属: Homo sapiens

同用名: CIS6; CISH6; Cish5; SOCS-5

基因 ID: 9655 | 基因类型: protein coding

关于 SOCS5

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:46,698,937-46,763,129 (from NCBI)

This gene has 4 transcripts (splice variants), 196 orthologues and 7 paralogues. Ubiquitous expression in ovary (RPKM 13.6), endometrium (RPKM 9.7) and 25 other tissues.

功能概要

该基因编码的蛋白质包含一个 SH2 结构域和一个 SOCS BOX 结构域。因此,该蛋白属于细胞因子信号转导抑制因子 (SOCS) 家族,也称为 STAT 诱导的 STAT 抑制剂 (SSI) 蛋白家族。已知 SOCS 家族成员是细胞因子信号转导的细胞因子诱导型负调节剂。这种蛋白质的具体功能尚未确定。已经报道了编码相同蛋白质的两种选择性剪接的转录物变体。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT Inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]

SOCS5 基因产物(2)

mRNA Protein Name
NM_014011.5 NP_054730.1 suppressor of cytokine signaling 5
NM_144949.3 NP_659198.1 suppressor of cytokine signaling 5
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15590694 GOA
enables receptor tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
15590694 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SOCS5 蛋白结构

SOCS

SOCS: Suppressor of cytokine signalling (144 - 197)

SH2

SH2: SH2 domain (382 - 436)

SOCS_box

SOCS_box: SOCS box (481 - 518)

  • 0
  • 100
  • 200
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  • 500
  • 536 a.a.
蛋白主名 其他名称

suppressor of cytokine signaling 5

CIS-6

SOCS5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SOCS5 O75159 MET Homo sapiens P08581
FPS
24728074
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Conjunctivitis

Madras Eye

Adenoviral Conjunctivitis

Acute Adenoviral Follicular Conjunctivitis

Inclusion Conjunctivitis Of The Adult

Swimming-Pool Conjunctivitis

Inflammation Of Conjunctiva

Ophthalmia

Acute Conjunctivitis

Eye Catarrh

Catarrhal Ophthalmia

Koch-Weeks Conjunctivitis

Small Intestine Leiomyosarcoma

Leiomyosarcoma Of The Small Bowel

Smooth Muscle Connective Tissue Tumor

Leiomyosarcoma Of Small Intestine

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SOCS5 MGD MGI:2385459
Canis familiaris SOCS5 VGNC VGNC:46652
Macaca mulatta SOCS5 VGNC VGNC:106222
Felis catus SOCS5 VGNC VGNC:65564
Bos taurus SOCS5 VGNC VGNC:35123
Rattus norvegicus SOCS5 RGD RGD:1564914