1. Gene
  2. SLK - STE20 like kinase Gene

SLK - STE20 like kinase Gene

中文名称:STE20 样激酶

种属: Homo sapiens

同用名: LOSK; STK2; se20-9; bA16H23.1

基因 ID: 9748 | 基因类型: protein coding

关于 SLK

Cytogenetic location: 10q24.33-q25.1 Genomic coordinates (GRCh38): 10:103,967,140-104,029,233 (from NCBI)

This gene has 4 transcripts (splice variants), 273 orthologues and 35 paralogues. Ubiquitous expression in esophagus (RPKM 35.4), lung (RPKM 15.9) and 25 other tissues.

功能概要

启用蛋白质同二聚化活性和蛋白质丝氨酸/苏氨酸激酶活性。参与多个过程,包括细胞质微管组织;蛋白质自身磷酸化;粘着斑组装的调节。位于细胞质的核周区。 [由基因组资源联盟提供,2022 年 4 月]

Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including cytoplasmic microtubule organization; protein autophosphorylation; and regulation of focal adhesion assembly. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SLK 基因产物(2)

mRNA Protein Name
NM_001304743.2 NP_001291672.1 STE20-like serine/threonine-protein kinase isoform 2
NM_014720.4 NP_055535.2 STE20-like serine/threonine-protein kinase isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18239682 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25882817 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
18239682 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
18239682 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytoplasmic microtubule organization IMP
IMP: 通过突变表型推断
18287541 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
18239682 GOA
involved in regulation of apoptotic process IDA
IDA: 通过直接分析推断
22203681 GOA
involved in regulation of cell migration IMP
IMP: 通过突变表型推断
26818812 GOA
involved in regulation of focal adhesion assembly IDA
IDA: 通过直接分析推断
23128389 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18287541 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
26094769 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SLK 蛋白结构

Pkinase

Pkinase: Protein kinase domain (34 - 292)

PKK

PKK: Polo kinase kinase (851 - 990)

PKK

PKK: Polo kinase kinase (1019 - 1160)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1235 a.a.
蛋白主名 其他名称

STE20-like serine/threonine-protein kinase

CTCL tumor antigen se20-9

SLK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLK Q9H2G2 HSPA9 Homo sapiens P38646 30021884
种属内
SLK Q9H2G2 SLK Homo sapiens Q9H2G2 18239682
种属内
SLK Q9H2G2 SLK Homo sapiens Q9H2G2 18239682
种属内
SLK Q9H2G2 a0a380pi90_yerpe Yersinia pestis A0A380PI90 20711500
种属内
SLK Q9H2G2 SLK Homo sapiens Q9H2G2 18239682
种属内
SLK Q9H2G2 AIFM1 Homo sapiens O95831 30021884
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Advanced Sleep Phase Syndrome, Familial, 1

Advanced Sleep Phase Syndrome 1

FASPS1

Familial Advanced Sleep Phase Syndrome 1

Sleep Phase Syndrome, Advanced, Familial, Type 1

Advanced Sleep Phase Syndrome, Familial, 3

Advanced Sleep Phase Syndrome 3

FASPS3

Familial Advanced Sleep Phase Syndrome 3

Sleep Phase Syndrome, Advanced, Familial, Type 3

Acute Kidney Failure

Acute Renal Failure

Acute Kidney Injury

Renal Failure Acute

Kidney Failure, Acute

Pre-Renal Acute Kidney Injury

Nontraumatic Acute Kidney Injury

Aki - [Acute Kidney Injury]

Arf - [Acute Kidney Failure]

Acute Kidney Disease

Acute Kidney Impairment

Acute Ischaemic Renal Failure

Acute Hypoxic Kidney Failure

Acute Kidney Shutdown

Acute Renal Oedema

Acute Renal Impairment

Acute Kidney Collapse

Acute Necrotising Kidney

Acute Renal Suppression

Inflammatory Bowel Disease 7

IBD7

Autoimmune Glomerulonephritis
Alzheimer Disease 3

AD3

Alzheimer Disease, Type 3

Alzheimer Disease, Type 3, With Spastic Paraparesis And Apraxia

Alzheimer Disease, Type 3, With Spastic Paraparesis And Unusual Plaques

Alzheimer'S Disease 3

Alzheimer Disease, Familial, 3, With Spastic Paraparesis And Apraxia

Alzheimer Disease 3, Early-Onset

Alzheimer Disease, Familial, 3

Alzheimer Disease, Protection Against, Due To Apoe3-Christchurch

Alzheimer Disease 3, Early Onset

Alzheimer Disease Familial 3

Early-Onset Familial Alzheimer Disease 3

Familial Alzheimer Disease 3

Familial Alzheimer Disease 3 With Spastic Paraparesis And Apraxia

Familial Alzheimer Disease 3 With Spastic Paraparesis And Unusual Plaques

Alzheimer Disease, Familial, 3, With Spastic Paraparesis And Unusual Plaques

Alzheimer Disease, Familial, Type 3

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SLK RGD RGD:3780
Mus musculus SLK MGD MGI:103241
Felis catus SLK VGNC VGNC:97634
Macaca mulatta SLK VGNC VGNC:81575
Bos taurus SLK VGNC VGNC:34968
Canis familiaris SLK VGNC VGNC:46512
Others SLK NCBI