CEP350 - centrosomal protein 350 Gene

中文名称：中心体蛋白 350

种属: Homo sapiens

同用名: GM133; CAP350

关于 CEP350

功能概要

该基因的产物是一种大蛋白，具有通常在细胞骨架相关蛋白中发现的 CAP-Gly 结构域。编码的蛋白质主要定位于中心体，中心体是一种非膜细胞器，在动物细胞中充当主要的微管组织中心。编码的蛋白质直接与另一个大的中心体蛋白相互作用，并且需要将微管锚定在中心体上。它还与细胞核中一类核激素受体的调节有关。已经发现了几种可变剪接的转录本变体，但尚未确定它们的全长性质。[RefSeq 提供，2008 年 7 月]

The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]