2. Gene
  3. RHOBTB1 - Rho related BTB domain containing 1 Gene

RHOBTB1 - Rho related BTB domain containing 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 Rho 相关 BTB 域 1

种属: Homo sapiens

基因 ID: 9886 | 基因类型: protein coding

关于 RHOBTB1

Cytogenetic location: 10q21.2 Genomic coordinates (GRCh38): 10:60,860,860-61,001,967 (from NCBI)

This gene has 6 transcripts (splice variants), 164 orthologues and 22 paralogues. Broad expression in placenta (RPKM 10.3), kidney (RPKM 7.3) and 22 other tissues.

功能概要

该基因编码的蛋白质属于小 GTPase 超家族的 Rho 家族。它包含一个 GTPase 结构域、一个富含脯氨酸的区域、串联的 2 个 BTB (广泛复合物、电车轨道和 bric-a-brac) 结构域，以及一个保守的 C 末端区域。该蛋白在小 GTPase 介导的信号转导和肌动蛋白丝系统的组织中发挥作用。交替剪接导致多个转录本变体。[RefSeq 提供，2008 年 12 月]

The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

RHOBTB1 基因产物(12)

mRNA Protein Name
NM_001242359.2 NP_001229288.1 rho-related BTB domain-containing protein 1 isoform 1
NM_001350902.2 NP_001337831.1 rho-related BTB domain-containing protein 1 isoform 1
NM_001350903.2 NP_001337832.1 rho-related BTB domain-containing protein 1 isoform 1
NM_001350904.2 NP_001337833.1 rho-related BTB domain-containing protein 1 isoform 1
NM_001350905.2 NP_001337834.1 rho-related BTB domain-containing protein 1 isoform 1
NM_001350906.2 NP_001337835.1 rho-related BTB domain-containing protein 1 isoform 2
NM_001350907.2 NP_001337836.1 rho-related BTB domain-containing protein 1 isoform 2
NM_001350908.2 NP_001337837.1 rho-related BTB domain-containing protein 1 isoform 2
NM_001350909.2 NP_001337838.1 rho-related BTB domain-containing protein 1 isoform 2
NM_001350910.2 NP_001337839.1 rho-related BTB domain-containing protein 1 isoform 2
NM_001350911.2 NP_001337840.1 rho-related BTB domain-containing protein 1 isoform 2
NM_014836.5 NP_055651.1 rho-related BTB domain-containing protein 1 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RHOBTB1 蛋白结构

Ras

Ras: Ras family (16 - 207)

BTB

BTB: BTB/POZ domain (404 - 455)

BTB

BTB: BTB/POZ domain (476 - 581)

  • 0
  • 200
  • 400
  • 600
  • 696 a.a.
蛋白主名 其他名称

rho-related BTB domain-containing protein 1

RHOBTB1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RHOBTB1 O94844 PRKCA Homo sapiens P17252
Y2H Array
32814053
种属内
RHOBTB1 O94844 PRKCA Homo sapiens P17252
Validated Y2H
32814053
种属内
RHOBTB1 O94844 PRKCA Homo sapiens P17252
Y2H Pooling
32814053
种属内
RHOBTB1 O94844 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
种属内
RHOBTB1 O94844 YWHAG Homo sapiens P61981
Validated Y2H
32814053
种属内
RHOBTB1 O94844 YWHAG Homo sapiens P61981
Y2H Array
32814053
种属内
RHOBTB1 O94844 KAT5 Homo sapiens Q92993
Validated Y2H
32814053
种属内
RHOBTB1 O94844 KAT5 Homo sapiens Q92993
Y2H Array
32814053
种属内
RHOBTB1 O94844 KAT5 Homo sapiens Q92993
Y2H Pooling
32814053
种属内
RHOBTB1 O94844 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
种属内
RHOBTB1 O94844 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
种属内
RHOBTB1 O94844 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ascaridiasis

Ascariasis
Toxic Megacolon

Megacolon, Toxic

Toxic Dilatation Of Colon

Toxic Functional Megacolon
Clostridium Difficile Colitis

Pseudomembranous Colitis

Colitis Pseudomembranous

Enterocolitis, Pseudomembranous

Pseudomembranous Enterocolitis

Clostridium Difficile Infection
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11947 RHOBTB1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus RHOBTB1 VGNC VGNC:33945
Rattus norvegicus RHOBTB1 RGD RGD:1306871
Macaca mulatta RHOBTB1 VGNC VGNC:76768
Mus musculus RHOBTB1 MGD MGI:1916538
Canis familiaris RHOBTB1 VGNC VGNC:45556
Felis catus RHOBTB1 VGNC VGNC:64613
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