2. Gene
  3. HS3ST1 - heparan sulfate-glucosamine 3-sulfotransferase 1 Gene

HS3ST1 - heparan sulfate-glucosamine 3-sulfotransferase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：硫酸乙酰肝素-氨基葡萄糖 3-磺基转移酶 1

种属: Homo sapiens

同用名: 3OST; 3OST1

基因 ID: 9957 | 基因类型: protein coding

关于 HS3ST1

Cytogenetic location: 4p15.33 Genomic coordinates (GRCh38): 4:11,393,150-11,434,327 (from NCBI)

This gene has 3 transcripts (splice variants), 193 orthologues and 10 paralogues. Ubiquitous expression in urinary bladder (RPKM 2.8), gall bladder (RPKM 0.9) and 19 other tissues.

功能概要

硫酸乙酰肝素生物合成酶是产生无数不同的硫酸乙酰肝素精细结构的关键成分，这些精细结构可执行多种生物活性。由该基因编码的酶是硫酸乙酰肝素生物合成酶家族的一员。兼具硫酸乙酰肝素氨基葡萄糖 3-O-磺基转移酶活性和抗凝硫酸乙酰肝素转化活性，是抗凝乙酰肝素合成的限速酶。这种酶是腔内高尔基常驻蛋白。[RefSeq 提供，2008 年 7 月]

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The Enzyme encoded by this gene is a member of the heparan sulfate biosynthetic Enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting Enzyme for synthesis of anticoagulant heparan. This Enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008]

HS3ST1 基因产物(1)

mRNA Protein Name
NM_005114.4 NP_005105.1 heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor

HS3ST1 蛋白结构

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (55 - 294)

  • 0
  • 100
  • 200
  • 307 a.a.
蛋白主名 其他名称

heparan sulfate glucosamine 3-O-sulfotransferase 1

3-OST-1

重组 HS3ST1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76974 HS3ST1 Protein, Human (sf9, His) O14792 (R21-H307) ≥95%

关联疾病

疾病名称 别名
Arteriosclerosis

Arteriosclerotic Vascular Disease
Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries
Acute Retinal Necrosis Syndrome

Acute Retinal Necrosis

Retinal Necrosis Syndrome, Acute
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06377 HS3ST1 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta HS3ST1 VGNC VGNC:73525
Rattus norvegicus HS3ST1 RGD RGD:71084
Mus musculus HS3ST1 MGD MGI:1201606
Bos taurus HS3ST1 VGNC VGNC:29958
Canis familiaris HS3ST1 VGNC VGNC:41791
Others HS3ST1 NCBI
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