1. Academic Validation
  2. Novel vitamin E derivative with 4-substituted resorcinol moiety has both antioxidant and tyrosinase inhibitory properties

Novel vitamin E derivative with 4-substituted resorcinol moiety has both antioxidant and tyrosinase inhibitory properties

  • Lipids. 2001 Dec;36(12):1321-6. doi: 10.1007/s11745-001-0847-9.
K Shimizu 1 R Kondo K Sakai N Takeda T Nagahata T Oniki
Affiliations

Affiliation

  • 1 Department of Forest Products, Faculty of Agriculture, Kyushu University Graduate School, Fukuoka, Japan.
Abstract

A novel vitamin E derivative, (6"-hydroxy-2",5",7",8"-tetramethylchroman-2"-yl)methyl 3-(2',4'-dihydroxyphenyl)propionate (TM4R), which has a chromanoxyl ring and 4-substituted resorcinol moieties, was synthesized; and its inhibitory effects on Tyrosinase, antioxidant ability, and lightening effect of ultraviolet B (UVB)-induced hyperpigmentation were estimated. TM4R showed potent inhibitory activity on Tyrosinase, which is the rate-limiting Enzyme in melanogenesis. The scavenging activities of TM4R on 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radicals were found to be nearly the same as those of alpha-tocopherol. Furthermore, an efficient lightening effect was observed following topical application of TM4R to UVB-stimulated hyperpigmented dorsal skin of brownish guinea pigs. These results suggest that TM4R may be a candidate for an efficient Whitening Agent, possibly by inhibiting Tyrosinase activity and biological reactions caused by Reactive Oxygen Species.

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