2. Academic Validation
  3. Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore

Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore

  • Bioorg Med Chem Lett. 2003 Jun 16;13(12):2025-7. doi: 10.1016/s0960-894x(03)00328-7.
Michael D Urbaniak 1,  Lisa M Frost,  John P Bingham,  Lloyd R Kelland,  John A Hartley,  Derek N Woolfson,  Stephen Caddick
Affiliations

Affiliation

  • 1 Center for Biomolecular Design and Drug Development, School of Chemistry, University of Sussex, Falmer, Brighton, BN1 9QJ, UK. s.caddick@sussex.ac.uk
PMID: 12781188 DOI: 10.1016/s0960-894x(03)00328-7
Abstract

Compounds containing the naphthoate moiety of Neocarzinostatin chromophore or 2-hydroxynaphthoate have been synthesized and evaluated for cytotoxic activity against a leukemia cell line and a small panel of human-tumor cell lines. Those compounds containing a cyclopentenone moiety were active, with the carbonyl group being essential for biological activity.

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