2. Academic Validation
  3. DNA topoisomerase I inhibitors from Rinorea anguifera

DNA topoisomerase I inhibitors from Rinorea anguifera

  • Bioorg Med Chem Lett. 2005 Feb 1;15(3):813-6. doi: 10.1016/j.bmcl.2004.10.095.
Ji Ma 1,  Shannon H Jones,  Rebekah Marshall,  Xihan Wu,  Sidney M Hecht
Affiliations

Affiliation

  • 1 Department of Chemistry and Department of Biology, University of Virginia, Charlottesville, VA 22901, USA.
PMID: 15664863 DOI: 10.1016/j.bmcl.2004.10.095
Abstract

An organic extract prepared from Rinorea anguifera was investigated in order to identify the natural principle(s) responsible for stabilization of a Topoisomerase I-DNA covalent binary complex. Bioassay-guided fractionation resulted in the isolation of mauritianin and (+)-syringaresinol as new Topoisomerase I inhibitors, and also of the known inhibitor camptothecin.

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