2. Academic Validation
  3. Synthesis of some floctafenine derivatives of expected anti-inflammatory/analgesic activity

Synthesis of some floctafenine derivatives of expected anti-inflammatory/analgesic activity

  • Arch Pharm (Weinheim). 2005 Aug;338(8):378-84. doi: 10.1002/ardp.200400959.
Gehan Hegazy Hegazy 1,  Azza Taher,  Asmaa Ahmed El-Zaher
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
PMID: 16041835 DOI: 10.1002/ardp.200400959
Abstract

New derivatives related to floctafenine were synthesized and representative examples were screened for their anti-inflammatory and analgesic activities. All compounds tested were found to exhibit anti-inflammatory and analgesic activities and some were more potent than the references, floctafenine and indomethacin, in carragenan-induced rat's paw edema. None of the tested compounds showed an ulcerogenic effect on the p-benzoquinone-induced writhing test in mice.

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