2. Academic Validation
  3. Purmorphamine activates the Hedgehog pathway by targeting Smoothened

Purmorphamine activates the Hedgehog pathway by targeting Smoothened

  • Nat Chem Biol. 2006 Jan;2(1):29-30. doi: 10.1038/nchembio753.
Surajit Sinha 1,  James K Chen
Affiliations

Affiliation

  • 1 Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA.
PMID: 16408088 DOI: 10.1038/nchembio753
Abstract

Hedgehog (Hh) signaling is an important regulator of embryonic patterning, tissue regeneration, stem cell renewal and Cancer growth. A purine derivative named purmorphamine was previously found to activate the Hh pathway and affect osteoblast differentiation through an unknown mechanism. We demonstrate here that purmorphamine directly targets Smoothened, a critical component of the Hh signaling pathway.

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