2. Academic Validation
  3. Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand

Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand

  • Bioorg Med Chem Lett. 2006 Oct 1;16(19):5001-4. doi: 10.1016/j.bmcl.2006.07.056.
Scott E Wolkenberg 1,  Zhijian Zhao,  Marianna Kapitskaya,  Andrea L Webber,  Konstantin Petrukhin,  Yui Sing Tang,  Dennis C Dean,  George D Hartman,  Craig W Lindsley
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Technology Enabled Synthesis Group, Merck & Co., Inc., PO Box 4, West Point, PA 19486, USA. scott_wolkenberg@merck.com
PMID: 16879962 DOI: 10.1016/j.bmcl.2006.07.056
Abstract

Agonists of NR2E3 (PNR, RNR) have been identified and optimized to EC(50)< 200 nM. A tritiated analogue of one agonist was prepared to aid in the development of a binding assay.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z