2. Academic Validation
  3. Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2

Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2

  • Arch Pharm Res. 2007 Mar;30(3):270-4. doi: 10.1007/BF02977605.
Rui Liu 1,  Tianjiao Zhu,  Dehai Li,  Jingyan Gu,  Wei Xia,  Yuchun Fang,  HongbingLiu,  Weiming Zhu,  Qianqun Gu
Affiliations

Affiliation

  • 1 Key laboratory of Marine Drugs, Chinese Ministry of Education, Qingdao 266003, PR China.
PMID: 17424930 DOI: 10.1007/BF02977605
Abstract

Bioassay-guided fractionation of the EtOAc extract from the fermentation broth of a marine-derived actinomycete Z(2)039-2 led to the isolation of two known indolocarbazole Alkaloids, K252c (1) and arcyriaflavin A (2). 1 and 2 exhibited moderate cytotoxic activities against the K562 cell line, and induced apoptotic activities at 10 and 100 microM, respectively. This is the first report on the significant Apoptosis inducing effect of indolocarbazole Alkaloids against K562 Cancer cells.

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