2. Academic Validation
  3. Dipeptidyl nitrile inhibitors of Cathepsin L

Dipeptidyl nitrile inhibitors of Cathepsin L

  • Bioorg Med Chem Lett. 2009 Aug 1;19(15):4280-3. doi: 10.1016/j.bmcl.2009.05.071.
Nabil Asaad 1,  Paul A Bethel,  Michelle D Coulson,  Jack E Dawson,  Susannah J Ford,  Stefan Gerhardt,  Matthew Grist,  Gordon A Hamlin,  Michael J James,  Emma V Jones,  Galith I Karoutchi,  Peter W Kenny,  Andrew D Morley,  Keith Oldham,  Neil Rankine,  David Ryan,  Stuart L Wells,  Linda Wood,  Martin Augustin,  Stephan Krapp,  Hannes Simader,  Stefan Steinbacher
Affiliations

Affiliation

  • 1 Respiratory & Inflammation Research Area, AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, UK.
PMID: 19515558 DOI: 10.1016/j.bmcl.2009.05.071
Abstract

A series of potent Cathepsin L inhibitors with good selectivity with respect to other cysteine Cathepsins is described and SAR is discussed with reference to the crystal structure of a protein-ligand complex.

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