2. Academic Validation
  3. New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides

New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides

  • Bioorg Med Chem Lett. 2010 Mar 1;20(5):1520-3. doi: 10.1016/j.bmcl.2010.01.095.
Satoru Tamura 1,  Bruno Kilunga Kubata,  Syamsurizal,  Sawako Itagaki,  Toshihiro Horii,  Muzele Kalulu Taba,  Nobutoshi Murakami
Affiliations

Affiliation

  • 1 Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
PMID: 20149652 DOI: 10.1016/j.bmcl.2010.01.095
Abstract

A new phenylpropanoid conjugated iridoid together with four known congeners was isolated from Morinda morindoides, used for the therapy of malaria traditionally in some African countries, as anti-malarial principles through bioassay-guided separation. Furthermore, their absolute stereostructures were unambiguously established by a combination of modified Mosher's method and chemical correlation.

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