2. Academic Validation
  3. Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp. K07-0010

Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp. K07-0010

  • J Antibiot (Tokyo). 2012 Apr;65(4):197-202. doi: 10.1038/ja.2011.139.
Junko Hashida 1,  Megumi Niitsuma,  Masato Iwatsuki,  Mihoko Mori,  Aki Ishiyama,  Miyuki Namatame,  Aki Nishihara-Tsukashima,  Atsuko Matsumoto,  Ismet Ara,  Yoko Takahashi,  Haruki Yamada,  Kazuhiko Otoguro,  Kazuro Shiomi,  Satoshi Omura
Affiliations

Affiliation

  • 1 Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
PMID: 22274704 DOI: 10.1038/ja.2011.139
Abstract

Two new isochromans, panowamycins A and B, were purified by solvent extraction, silica gel and octadecylsilyl silica gel (ODS) column chromatography followed by preparative HPLC, from a culture broth of Streptomyces sp. K07-0010, together with the known compounds NFAT-133, conglobatin, piericidin C series and dinactin. Structures of panowamycins were elucidated as new analogs of NFAT-133 by spectroscopic studies including various NMR experiments. Panowamycins A and B showed moderate antitrypanosomal activity, with IC(50) values of 0.40 and 3.30 μg ml(-1), respectively.

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