1. Academic Validation
  2. Osteoclast-inhibiting saikosaponin derivatives from Bupleurum chinense

Osteoclast-inhibiting saikosaponin derivatives from Bupleurum chinense

  • Fitoterapia. 2013 Mar;85:101-8. doi: 10.1016/j.fitote.2013.01.005.
Jin-Qian Yu 1 An-Jun Deng Lian-Qiu Wu Zhi-Hui Zhang Yang Liu Wen-Jie Wang Hai-Lin Qin
Affiliations

Affiliation

  • 1 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China. fish@imm.ac.cn
Abstract

Five new saikosaponins, saikosaponin w (1), 21β-hydroxysaikosaponin b2 (2), 6″-O-acetylsaikosaponin e (3), 6″-O-acetylsaikosaponin b1 (4), and 6″-O-acetylsaikosaponin b3 (5), along with twenty-two known ones (6-27), have been isolated from the roots of Bupleurum chinense. Their structures were elucidated on the basis of detailed spectroscopic analysis, including mainly 1D and 2D NMR and HRESI-MS, qualitative chemical methods, and comparison with the literatures. Osteoclast-inhibiting activity of some of the isolated compounds was evaluated in vitro, with five ones have shown significant activity by inhibitory rates ranging from 48.3% to 56.1% at the concentration of 10μM and with significant differences among groups observed.

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