2. Academic Validation
  3. Determination of prostaglandin analogs in cosmetic products by high performance liquid chromatography with tandem mass spectrometry

Determination of prostaglandin analogs in cosmetic products by high performance liquid chromatography with tandem mass spectrometry

  • J Chromatogr A. 2014 Sep 12:1359:140-6. doi: 10.1016/j.chroma.2014.07.032.
James B Wittenberg 1,  Wanlong Zhou 2,  Perry G Wang 2,  Alexander J Krynitsky 2
Affiliations

Affiliations

  • 1 U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, HFS-717, College Park, MD 20740-3835, USA. Electronic address: James.Wittenberg@fda.hhs.gov.
  • 2 U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, HFS-717, College Park, MD 20740-3835, USA.
PMID: 25085824 DOI: 10.1016/j.chroma.2014.07.032
Abstract

A method was developed and validated for the determination of 16 prostaglandin analogs in cosmetic products. The QuEChERS (Quick, Easy, Cheap, Efficient, Rugged, Safe) liquid-liquid extraction method, typically used for pesticide residue analysis, was utilized as the sample preparation technique. The prostaglandin analogs were chromatographically separated and quantified using high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). Thirty-one cosmetic products were surveyed, and 13 products were determined to contain a prostaglandin analog with amounts ranging from 27.4 to 297μg/g. The calculated concentrations for the cosmetic products were in a similar range when compared to the concentrations of three different prostaglandin analog-containing prescription products.

Keywords

Cosmetics; LC-MS/MS; Prostaglandins; QuEChERS.

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