2. Academic Validation
  3. Azide phosphoramidite in direct synthesis of azide-modified oligonucleotides

Azide phosphoramidite in direct synthesis of azide-modified oligonucleotides

  • Org Lett. 2014 Sep 5;16(17):4590-3. doi: 10.1021/ol502155g.
Maksim A Fomich 1,  Maksim V Kvach,  Maksim J Navakouski,  Christoph Weise,  Alexander V Baranovsky,  Vladimir A Korshun,  Vadim V Shmanai
Affiliations

Affiliation

  • 1 Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus , Surganova 13, 220072 Minsk, Belarus.
PMID: 25156193 DOI: 10.1021/ol502155g
Abstract

Azide and phosphoramidite functions were found to be compatible within one molecule and stable for months in solution kept frozen at -20 °C. An azide-carrying phosphoramidite was used for direct introduction of multiple azide modifications into synthetic Oligonucleotides. A series of azide-containing Oligonucleotides were modified further using click reactions with alkynes.

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