2. Academic Validation
  3. Stimulation of phosphorylation of ERK and CREB by phellopterin and auraptene isolated from Citrusjunos

Stimulation of phosphorylation of ERK and CREB by phellopterin and auraptene isolated from Citrusjunos

  • Nat Prod Commun. 2014 Oct;9(10):1491-4.
Mitsuhiro Nakamura,  Tomoko Suzuki,  Mai Takagi,  Hirotoshi Tamura,  Toshiya Masuda
PMID: 25522543
Abstract

Bioactive compounds from citrus fruits contribute many benefits to human health. Extracellular signal-regulated kinase (ERK) signaling plays an important role in the regulation of multiple cellular processes. Activation of the ERK-cAMP response element binding protein (CREB) signaling is required for long- term memory formation. In this study, auraptene, phellopterin, thymol, coniferyl alcohol 9-methyl ether and methyl ferulate were isolated from Citrus junos. Among the five compounds isolated, auraptene and phellopterin increased the phosphorylation of ERK and CREB. This study provides, to our knowledge, the first evidence that phellopterin potently stimulates the phosphorylation of ERK and CREB. Phellopterin could be a novel neuroprotective agent.

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