2. Academic Validation
  3. Anti-inflammatory activity of phenolic compounds from the whole plant of Scutellaria indica

Anti-inflammatory activity of phenolic compounds from the whole plant of Scutellaria indica

  • Bioorg Med Chem Lett. 2015 Mar 1;25(5):1129-34. doi: 10.1016/j.bmcl.2014.12.055.
To Dao Cuong 1,  Tran Manh Hung 1,  Joo-Sang Lee 1,  Kwon-Yeon Weon 1,  Mi Hee Woo 1,  Byung Sun Min 2
Affiliations

Affiliations

  • 1 College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea.
  • 2 College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea. Electronic address: bsmin@cu.ac.kr.
PMID: 25637363 DOI: 10.1016/j.bmcl.2014.12.055
Abstract

Six new phenolics, scutellariosides A-F (1-3, 5-6, and 8), together with six known compounds (4, 7, 9-12) were isolated from the whole plant of Scutellaria indica (Labiatae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR. Their anti-inflammatory activities were evaluated against LPS-induced NO production in macrophage RAW 264.7 cells. Among them, compounds 10-12 had inhibitory effects with IC50 values ranging from 7.2 to 27.8μM. Compound 12 reduced LPS-induced iNOS expression in a dose-dependent manner.

Keywords

Anti-inflammatory activity; Flavonoid; Labiatae; RAW 264.7 cells; Scutellaria indica.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z