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  3. TNF-α-inducing protein of Helicobacter pylori induces epithelial-mesenchymal transition (EMT) in gastric cancer cells through activation of IL-6/STAT3 signaling pathway

TNF-α-inducing protein of Helicobacter pylori induces epithelial-mesenchymal transition (EMT) in gastric cancer cells through activation of IL-6/STAT3 signaling pathway

  • Biochem Biophys Res Commun. 2017 Mar 4;484(2):311-317. doi: 10.1016/j.bbrc.2017.01.110.
Guodong Chen 1,  Na Tang 2,  Chao Wang 3,  Linqiao Xiao 4,  Minjun Yu 5,  Lanhua Zhao 6,  Hengling Cai 7,  Liang Han 8,  Chengyuan Xie 9,  Yan Zhang 10
Affiliations

Affiliations

  • 1 Institute of Pathogenic Biology, Medical College, University of South China, Hengyang 421001, Hunan, PR China. Electronic address: 815003608@qq.com.
  • 2 Institute of Pathogenic Biology, Medical College, University of South China, Hengyang 421001, Hunan, PR China. Electronic address: 374069569@qq.com.
  • 3 Institute of Pathogenic Biology, Medical College, University of South China, Hengyang 421001, Hunan, PR China. Electronic address: 1019338557@qq.com.
  • 4 Institute of Pathogenic Biology, Medical College, University of South China, Hengyang 421001, Hunan, PR China. Electronic address: 947761272@qq.com.
  • 5 Institute of Pathogenic Biology, Medical College, University of South China, Hengyang 421001, Hunan, PR China. Electronic address: 52813707@qq.com.
  • 6 Institute of Pathogenic Biology, Medical College, University of South China, Hengyang 421001, Hunan, PR China. Electronic address: zhaolanhua@126.com.
  • 7 Institute of Pathogenic Biology, Medical College, University of South China, Hengyang 421001, Hunan, PR China. Electronic address: 343968162@qq.com.
  • 8 Institute of Pathogenic Biology, Medical College, University of South China, Hengyang 421001, Hunan, PR China. Electronic address: hanliang0122@vip.qq.com.
  • 9 Institute of Pathogenic Biology, Medical College, University of South China, Hengyang 421001, Hunan, PR China. Electronic address: 3844843762@qq.com.
  • 10 Institute of Pathogenic Biology, Medical College, University of South China, Hengyang 421001, Hunan, PR China. Electronic address: nhzhangyan@126.com.
PMID: 28130110 DOI: 10.1016/j.bbrc.2017.01.110
Abstract

Tumor necrosis factor (TNF)-α-inducing protein (Tipα) is a newly identified carcinogenic factor secreted by Helicobacter pylori (H. pylori). Although it has been proved that Tipα is a strong inducer of epithelial-mesenchymal transition (EMT), a crucial process of migration, the exact molecular mechanism is unknown. Current evidence indicates that the oncogenic transcription factor signal transducers and activators of transcription 3 (STAT3) is inappropriately activated in multiple malignancies, including gastric Cancer. In this study, we showed that Tipα significantly down-regulated the expression of EMT-related markers E-cadherin as well as up-regulated N-Cadherin and vimentin in SGC7901 cells, with typical morphological changes of EMT. Tipα also promoted proliferation and migration of SGC7901 cells. Furthermore, Tipα activated interleukin-6 (IL-6)/STAT3 signaling pathway in SGC7901 cells. The effects of Tipα treatment observed was abolished when we block IL-6/STAT3 signaling pathway. Altogether, our data demonstrated that Tipα may accelerate tumor aggressiveness in gastric Cancer by promoting EMT through activation of IL-6/STAT3 pathway.

Keywords

Epithelial-mesenchymal transition (EMT); Gastric cancer; Helicobacter pylori; IL-6/STAT3 pathway; TNF-α inducing protein (Tipα).

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-16975
    99.45%, STAT3/5 抑制剂
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