2. Academic Validation
  3. The Effect of 4-hydroxybenzaldehyde on the γ-aminobutyric Acid Type A Receptor

The Effect of 4-hydroxybenzaldehyde on the γ-aminobutyric Acid Type A Receptor

  • Malays J Med Sci. 2017 Mar;24(2):94-99. doi: 10.21315/mjms2017.24.2.12.
Jingli Zhang 1,  Habsah Mohamad 2,  Jia Hui Wong 1,  Muhammad Bilal 1,  Abdul Hadi Bin Ismail 2,  Amelia Jane Lloyd 3 1,  Abdul Aziz Mohamed Yusoff 3 1,  Hasnah Osman 4,  Kok Tong Wong 4,  Zamzuri Idris 3 1 5,  Jafri Malin Abdullah 3 1 5
Affiliations

Affiliations

  • 1 Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Jalan Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
  • 2 Institut Bioteknologi Marin, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia.
  • 3 Center for Neuroscience Services and Research, Universiti Sains Malaysia, Jalan Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
  • 4 School of Chemical Sciences, Universiti Sains Malaysia, 11800 USM, Pulau Pinang, Malaysia.
  • 5 Jabatan Neurosains, Hospital Universiti Sains Malaysia, Jalan Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
PMID: 28894409 DOI: 10.21315/mjms2017.24.2.12
Abstract

The α1β2γ2 subtype of GABAA receptors is the most commonly found GABAA receptor subtype in the mammalian cortex and hippocampus. It is expressed heterologously in the Xenopus laevis oocyte as a α1β2γ2S/L subtype for application as an in vitro model for the screening of compounds that modulate receptor activities. In fact, 4-hydroxybenzaldehyde (4-HB) has been identified as one of the major components in Dendrocalamus asper bamboo shoots in our previous study, and the current study showed that at 101.7 μM, 4-HB significantly reduced the GABA-induced chloride current of GABAA receptors expressed on Xenopus oocytes, indicating a possible GABAergic antagonistic effect at high concentrations.

Keywords

GABAergic agents; Xenopus oocytes; bamboo shoot; electrophysiology; α1β2γ2 GABAA receptor.

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