2. Academic Validation
  3. Anti-depressive-like effect of 2-phenylethanol inhalation in mice

Anti-depressive-like effect of 2-phenylethanol inhalation in mice

  • Biomed Pharmacother. 2019 Mar:111:1499-1506. doi: 10.1016/j.biopha.2018.10.073.
Hiroshi Ueno 1,  Atsumi Shimada 2,  Shunsuke Suemitsu 3,  Shinji Murakami 4,  Naoya Kitamura 5,  Kenta Wani 6,  Yosuke Matsumoto 7,  Motoi Okamoto 8,  Takeshi Ishihara 9
Affiliations

Affiliations

  • 1 Department of Medical Technology, Kawasaki University of Medical Welfare, Okayama, 701-0193, Japan. Electronic address: dhe422007@s.okayama-u.ac.jp.
  • 2 Division of Food and Nutrition, Nakamura Gakuen University Junior College, Fukuoka, 814-0198, Japan. Electronic address: atsushimada@nakamura-u.ac.jp.
  • 3 Department of Psychiatry, Kawasaki Medical School, Okayama, 701-0192, Japan. Electronic address: ssue@med.kawasaki-m.ac.jp.
  • 4 Department of Psychiatry, Kawasaki Medical School, Okayama, 701-0192, Japan. Electronic address: muraka@med.kawasaki-m.ac.jp.
  • 5 Department of Psychiatry, Kawasaki Medical School, Okayama, 701-0192, Japan. Electronic address: n-kitamura@med.kawasaki-m.ac.jp.
  • 6 Department of Psychiatry, Kawasaki Medical School, Okayama, 701-0192, Japan. Electronic address: k-wani@med.kawasaki-m.ac.jp.
  • 7 Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, 700-8558, Japan. Electronic address: ymatsumoto@cc.okayama-u.ac.jp.
  • 8 Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Okayama, 700-8558, Japan. Electronic address: mokamoto@md.okayama-u.ac.jp.
  • 9 Department of Psychiatry, Kawasaki Medical School, Okayama, 701-0192, Japan. Electronic address: t-ishihara@med.kawasaki-m.ac.jp.
PMID: 30415864 DOI: 10.1016/j.biopha.2018.10.073
Abstract

Rose oil has traditionally been used to treat psychiatric disorders, but the scientific basis of this treatment remains poorly understood. The main odor component of rose oil is 2-phenylethanol (2-PE), but the neuropsychological effects of 2-PE have not been investigated in detail. Thus, we aimed to investigate the effects of 2-PE on mouse behavior. We first investigated whether 2-PE is attractive or repulsive to mice. After 2-PE inhalation, the mice underwent a series of behavioral experiments, such as the elevated plus maze, open field, Y-maze, tail-suspension, and Porsolt forced-swim tests. Mice did not have a strong interest in 2-PE but were not repelled by it nor were fearful. In the open field test, mice that had inhaled 2-PE spent less time in the center area, while in the tail suspension test, their immobility time decreased. There was no change in cognitive function, activity level, muscle strength, or aggression in these mice. Our results suggest that 2-PE elicits neuropsychological effects that alter the behavior of mice and may also elicit anti-depressive effects. Inhalation of rose oil containing 2-PE may be effective against depression and stress-related diseases.

Keywords

2-phenylethanol; Depression; Essential oil; Inhalation; Rose.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z