1. Academic Validation
  2. The role of interleukin-1 in general pathology

The role of interleukin-1 in general pathology

  • Inflamm Regen. 2019 Jun 6;39:12. doi: 10.1186/s41232-019-0101-5.
Naoe Kaneko 1 Mie Kurata 1 Toshihiro Yamamoto 1 Shinnosuke Morikawa 1 Junya Masumoto 1
Affiliations

Affiliation

  • 1 Department of Pathology, Ehime University Graduate School of Medicine and Proteo-Science Center, Shitsukawa 454, Toon, Ehime 791-0295 Japan.
Abstract

Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease. In this decade, interleukin-1 family members have been expanding and evidence is accumulating that highlights the importance of interleukin-1 in linking innate immunity with a broad spectrum of diseases beyond inflammatory diseases. In this review, we look back on the definition of "inflammation" in traditional general pathology and discuss new insights into interleukin-1 in view of its history and the molecular bases of diseases, as well as current progress in therapeutics.

Keywords

Cancer; Drug target; Inflammatory diseases; Interleukin-1; Metabolic inflammation.

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