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  3. Interleukin-1 reduces food intake and body weight in rat by acting in the arcuate hypothalamus

Interleukin-1 reduces food intake and body weight in rat by acting in the arcuate hypothalamus

  • Brain Behav Immun. 2019 Oct;81:560-573. doi: 10.1016/j.bbi.2019.07.017.
Léa Chaskiel 1,  Adrian D Bristow 2,  Rose-Marie Bluthé 1,  Robert Dantzer 3,  Anders Blomqvist 4,  Jan Pieter Konsman 5
Affiliations

Affiliations

  • 1 Psychoneuroimmunology, Nutrition and Genetics, UMR CNRS 5226-INRA 1286, University of Bordeaux, 33076 Bordeaux, France.
  • 2 National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK.
  • 3 Department of Symptom Research, MD Anderson Cancer Center, The University of Texas, Houston, TX 770030, USA.
  • 4 Division of Neurobiology, Department of Clinical and Experimental Medicine, Faculty of Medicine and Health Sciences, Linköping University, S-581 85 Linköping, Sweden.
  • 5 UMR CNRS 5287 Aquitaine Institute for Integrative and Cognitive Neuroscience, University of Bordeaux, 33076 Bordeaux, France. Electronic address: jan-pieter.konsman@u-bordeaux.fr.
PMID: 31310797 DOI: 10.1016/j.bbi.2019.07.017
Abstract

A reduction in food intake is commonly observed after Bacterial infection, a phenomenon that can be reproduced by peripheral administration of Gram-negative Bacterial lipopolysaccharide (LPS) or interleukin-1beta (IL-1β), a pro-inflammatory cytokine released by LPS-activated macrophages. The arcuate nucleus of the hypothalamus (ARH) plays a major role in food intake regulation and expresses IL-1 type 1 receptor (IL-1R1) mRNA. In the present work, we tested the hypothesis that IL-1R1 expressing cells in the ARH mediate IL-1β and/or LPS-induced hypophagia in the rat. To do so, we developed an IL-1β-saporin conjugate, which eliminated IL-R1-expressing neurons in the hippocampus, and micro-injected it into the ARH prior to systemic IL-1β and LPS administration. ARH IL-1β-saporin injection resulted in loss of neuropeptide Y-containing cells and attenuated hypophagia and weight loss after intraperitoneal IL-1β, but not LPS, administration. In conclusion, the present study shows that ARH NPY-containing neurons express functional IL-1R1s that mediate peripheral IL-1β-, but not LPS-, induced hypophagia. Our present and previous findings indicate that the reduction of food intake after IL-1β and LPS are mediated by different neural pathways.

Keywords

Arcuate nucleus; Hypophagia; Interleukin-1; Lipopolysaccharide; Neuropeptide Y.

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