Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization

Neelima Sinha ¹,  Navnath P Karche ¹,  Mahip Kalyan Verma ¹,  Sameer S Walunj ¹,  Prashant B Nigade ¹,  Gourhari Jana ¹,  Sanjay P Kurhade ¹,  Anil K Hajare ¹,  Ajay R Tilekar ¹,  Ganesh R Jadhav ¹,  Baban R Thube ¹,  Javed S Shaikh ¹,  Sudhakar Balgude ¹,  Lairikyengbam Bikramjit Singh ¹,  Vijaya Mahimane ¹,  Shridhar K Adurkar ¹,  Girish Hatnapure ¹,  Firoj Raje ¹,  Yogesh Bhosale ¹,  Dnyaneshwar Bhanage ¹,  Sachchidanand Sachchidanand ¹,  Ruchi Dixit ¹,  Rajesh Gupta ¹,  Anand M Bokare ¹,  Manoj Dandekar ¹,  Ashish Bharne ¹,  Manavi Chatterjee ¹,  Sagar Desai ¹,  Sarita Koul ¹,  Dipak Modi ¹,  Maneesh Mehta ¹,  Vinod Patil ¹,  Minakshi Singh ¹,  Jayasagar Gundu ¹,  Rajan N Goel ¹,  Chirag Shah ¹,  Sharad Sharma ¹,  Dhananjay Bakhle ¹,  Rajender Kumar Kamboj ¹,  Venkata P Palle ¹