2. Academic Validation
  3. The role of linagliptin, a selective dipeptidyl peptidase-4 inhibitor, in the morphine rewarding effects in rats

The role of linagliptin, a selective dipeptidyl peptidase-4 inhibitor, in the morphine rewarding effects in rats

  • Neurochem Int. 2020 Feb;133:104616. doi: 10.1016/j.neuint.2019.104616.
Małgorzata Łupina 1,  Sylwia Talarek 2,  Jolanta Kotlińska 3,  Ewa Gibuła-Tarłowska 4,  Piotr Listos 5,  Joanna Listos 6
Affiliations

Affiliations

  • 1 Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodźki 4a St., 20-093, Lublin, Poland. Electronic address: lupina.malgorzata@gmail.com.
  • 2 Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodźki 4a St., 20-093, Lublin, Poland. Electronic address: sylwia.talarek@umlub.pl.
  • 3 Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodźki 4a St., 20-093, Lublin, Poland. Electronic address: jolanta.kotlinska@umlub.pl.
  • 4 Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodźki 4a St., 20-093, Lublin, Poland. Electronic address: ewa.gibulabruzda@umlub.pl.
  • 5 Department and Clinic of Animal Internal Diseases, Sub-Department of Pathomorphology and Forensic Medicine, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 30 Av, 20-612, Lublin, Poland. Electronic address: piotr.listos@up.lublin.pl.
  • 6 Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodźki 4a St., 20-093, Lublin, Poland. Electronic address: joannalistos@umlub.pl.
PMID: 31809774 DOI: 10.1016/j.neuint.2019.104616
Abstract

Linagliptin is a selective dipeptidyl peptidase-4 (DPP-4) inhibitor which suppresses the rapid degradation of endogenous glucagon-like peptide-1 (GLP-1). In clinical practice, it is used as an antidiabetic drug, but recent studies have confirmed its role in the activity of the central nervous system (CNS). The reported study focused on the role of linagliptin (10 and 20 mg/kg, ip) in the morphine rewarding effect, analyzing how the agent had influenced the conditioned place preference (CPP) in rats via the expression, acquisition, extinction and reinstatement of the morphine rewarding effect. The obtained results clearly demonstrated linagliptin to inhibit the expression and acquisition, to accelerate the extinction and, eventually, to reduce the reinstatement of morphine-induced CPP. The undertaken experiments significantly extended our knowledge on the mechanisms behind the morphine rewarding effect.

Keywords

Conditioned place preference test; Dipeptidyl peptidase-4; Glucagon-like peptide-1; Linagliptin; Morphine; Rewarding effect.

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