1. Academic Validation
  2. Effects of polysaccharides from wild morels on immune response and gut microbiota composition in non-treated and cyclophosphamide-treated mice

Effects of polysaccharides from wild morels on immune response and gut microbiota composition in non-treated and cyclophosphamide-treated mice

  • Food Funct. 2020 May 1;11(5):4291-4303. doi: 10.1039/d0fo00597e.
Wenyan Huo 1 Zhengping Feng Suying Hu Langjun Cui Ting Qiao Lu Dai Peng Qi Liguang Zhang Yu Liu Junzhi Li
Affiliations

Affiliation

  • 1 Fungal Research Center, Shaanxi Provincial Institute of Microbiology, Xi'an 710043, Shaanxi, China. xianjunzhi@163.com.
Abstract

Polysaccharides isolated from mushrooms have been identified as potential prebiotics that could impact gut microbiota. In this study, a water-soluble polysaccharide (MP) extracted from wild morels was evaluated for its effects on the gut microbiota of non-treated and cyclophosphamide (CP)-treated mice. The results showed that MP restored the spleen weight and increased the counts of white blood cells and lymphocytes in the peripheral blood and spleen of the CP-treated mice. Mice treated with MP exhibited increased levels of short-chain fatty acid (SCFA)-producing bacteria, especially Lachnospiraceae, compared to normal mice, and increased levels of Bacteroidetes and SCFA-producing bacteria, especially Ruminococcaceae, compared to the CP-treated mice. Moreover, MP treatment increased the production of valeric acid and decreased the production of acetic acid in the non-treated mice and increased the production of acetic acid, propionic acid, butyric acid, and valeric acid in the CP-treated mice. These results show that MP is potentially good for health.

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