2. Academic Validation
  3. Oxidative stress and DNA damage in earthworm (Eisenia fetida) induced by triflumezopyrim exposure

Oxidative stress and DNA damage in earthworm (Eisenia fetida) induced by triflumezopyrim exposure

  • Chemosphere. 2021 Feb;264(Pt 2):128499. doi: 10.1016/j.chemosphere.2020.128499.
Shengfang Wen 1,  Chao Liu 2,  Youwei Wang 3,  Yannan Xue 4,  Xueting Wang 5,  Jinhua Wang 6,  Xiaoming Xia 7,  Young Mo Kim 8
Affiliations

Affiliations

  • 1 College of Plant Protection, Shandong Agricultural University, Tai'an, PR China. Electronic address: wsf0887@163.com.
  • 2 College of Plant Protection, Shandong Agricultural University, Tai'an, PR China. Electronic address: liuchao19950519@163.com.
  • 3 College of Plant Protection, Shandong Agricultural University, Tai'an, PR China. Electronic address: 984264362@qq.com.
  • 4 College of Plant Protection, Shandong Agricultural University, Tai'an, PR China. Electronic address: XYN81926@163.com.
  • 5 College of Plant Protection, Shandong Agricultural University, Tai'an, PR China. Electronic address: 1417287076@qq.com.
  • 6 College of Resources and Environment, Shandong Agricultural University, Tai'an, PR China. Electronic address: wjh@sdau.edu.cn.
  • 7 College of Plant Protection, Shandong Agricultural University, Tai'an, PR China. Electronic address: xxm@sdau.edu.cn.
  • 8 Department of Civil and Environmental Engineering, Hanyang University, Seongdong-gu, Seoul, 04763, Republic of Korea. Electronic address: youngmo@hanyang.ac.kr.
PMID: 33049500 DOI: 10.1016/j.chemosphere.2020.128499
Abstract

Triflumezopyrim is an excellent pesticide for preventing and controlling rice planthoppers. It is widely used in the production of field rice and mainly through spraying with some inadvertent loss of pesticide to the soil. The future may bring development and utilization of seeds containing triflumezopyrim which will certainly impact earthworms. To evaluate the toxic effects of triflumezopyrim on earthworms, Reactive Oxygen Species (ROS), superoxide dismutase (SOD) and catalase (CAT) activities, malondialdehyde content (MDA), glutathione S-transferase (GST), and DNA oxidative damage (8-hydroxy-2'-deoxyguanosine, 8-OHdG) were measured after 7, 14, 21, and 28 d analyzing the effects of 6 concentrations (0, 0.5, 1, 2.5, 5 and 10 mg/kg) of triflumezopyrim, respectively. ROS content did not change significantly in the early stages but showed a significant dose-effect relationship in the late stages. Antioxidant enzymes were activated in most treatment groups, and catalase activity was the same as that in the control group at 28 d. GST activity showed a trend of increasing first and then decreasing whereas MDA content had no obvious change in trend. 8-OHdG showed significant positive correlation with the concentration of triflumezopyrim at 28 d, indicating that the degree of DNA oxidative damage increased accordingly. The results showed that chronic exposure of triflumezopyrim may cause both oxidative stress and DNA damage in earthworms and alter the activity of antioxidant enzymes.

Keywords

Antioxidant enzyme; DNA damage; Earthworm; Triflumezopyrim.

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