2. Academic Validation
  3. Cannabisin D from Sinomenium Acutum Inhibits Proliferation and Migration of Glioblastoma Cells through MAPKs Signaling

Cannabisin D from Sinomenium Acutum Inhibits Proliferation and Migration of Glioblastoma Cells through MAPKs Signaling

  • Nutr Cancer. 2021;73(11-12):2491-2501. doi: 10.1080/01635581.2020.1836240.
Dianbao Zhang 1,  Chunhe Li 2,  Luting Zhang 2,  Bo Li 2,  Yu Wang 2,  Rui Wang 1,  Zaixing Chen 3,  Liang Xu 4,  Tao Liu 2
Affiliations

Affiliations

  • 1 Department of Stem Cells and Regenerative Medicine, Key Laboratory of Cell Biology, National Health Commission of China, and Key Laboratory of Medical Cell Biology, Ministry of Education of China, China Medical University, Shenyang, China.
  • 2 Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang, China.
  • 3 Department of the Central Laboratory, School of Pharmacy, China Medical University, Shenyang, China.
  • 4 College of Traditional Chinese Medicine, Liaoning University of Traditional Chinese Medicine, Dalian, China.
PMID: 33076708 DOI: 10.1080/01635581.2020.1836240
Abstract

Glioblastoma is the most common and malignant tumor in human central nervous system with poor prognosis. From the dried stem of Sinomenium acutum, an herbal medicine, five compounds (sinomenine, syringin, corchoionoside C, protocatechuic acid and cannabisin D) were isolated, characterized and subjected to cytotoxicity screening on U-87 and U-251 glioblastoma cells. Cannabisin D presented effective inhibitory effects on the proliferation and migration of glioblastoma cells. By flow cytometry, Real-Time PCR and Western blotting, cell Apoptosis and cell cycle arrest were proved to contribute to the anti-glioblastoma effects. Further, the activation of MAPKs signaling (p38 MAPK, p42/p44 MAPK and SAPK/JNK) was observed in glioblastoma cells upon cannabisin D treatment by Western blotting, indicating the involvement of MAPKs signaling in the inhibitory effects of cannabisin D. These data suggested that S. acutum is a novel natural source of cannabisin D and cannabisin D is a novel anti-glioblastoma agent candidate.

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