2. Academic Validation
  3. Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress

Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress

  • Mol Cell Endocrinol. 2021 Mar 1;523:111144. doi: 10.1016/j.mce.2020.111144.
Qing-Liang Wen 1,  He-Qing Yi 2,  Ke Yang 3,  Chang-Tian Yin 4,  Wen-Juan Yin 5,  Fang-Yue Xiang 6,  Miao Bao 7,  Jing Shuai 8,  Yi-Wei Song 9,  Ming-Hua Ge 10,  Xin Zhu 11
Affiliations

Affiliations

  • 1 Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China; Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China; Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, China. Electronic address: wenqingliang91@163.com.
  • 2 Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China; Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China; Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, China. Electronic address: yiheqing1980@163.com.
  • 3 Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China; Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China; Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, China. Electronic address: yangke@zjcc.org.cn.
  • 4 Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China. Electronic address: yin454593539@163.com.
  • 5 Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China; Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China; Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, China. Electronic address: wjyin123@163.com.
  • 6 Stomatology College, Zhejiang Chinese Medical University, Hangzhou, China. Electronic address: 812492033@qq.com.
  • 7 Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China. Electronic address: miaomiao930930@163.com.
  • 8 Stomatology College, Zhejiang Chinese Medical University, Hangzhou, China. Electronic address: meilinsj@163.com.
  • 9 Stomatology College, Zhejiang Chinese Medical University, Hangzhou, China. Electronic address: songyiwei0807@126.com.
  • 10 Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China. Electronic address: geminghua@hmc.edu.cn.
  • 11 Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China; Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China; Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, China. Electronic address: zhuxin@zjcc.org.cn.
PMID: 33383107 DOI: 10.1016/j.mce.2020.111144
Abstract

In this study, we aimed to clarify the role of PIM-1 in papillary thyroid carcinoma (PTC) in vitro and investigate the relationship between PIM-1 and redox proteins (NOX4, SOD2, and GPX2) at the tissue and cellular levels. As a PIM-1 inhibitor, SGI-1776 inhibited cell proliferation, colony formation, migration and induced an increase in Apoptosis and Reactive Oxygen Species in two PTC cell lines (BCPAP and TPC-1). The expressions of PIM-1, SOD2 and GPX2 were downregulated after siNOX4 exposure. Immunohistochemistry in 120 PTC patients showed that all four proteins exhibited higher expression levels in PTC tissues than in adjacent normal tissues. PIM-1 expression was related to NOX4, SOD2, and GPX2 expressions. The Cancer Genome Atlas database analysis showed the significant correlation between the expression of NOX4 and PIM-1. Our results demonstrated that PIM-1 played an important oncogenic role in PTC carcinogenesis that may be related to oxidative stress.

Keywords

NOX4; Oxidative stress; PIM-1; Papillary thyroid carcinoma.

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