2. Academic Validation
  3. USP11 induce resistance to 5-Fluorouracil in Colorectal Cancer through activating autophagy by stabilizing VCP

USP11 induce resistance to 5-Fluorouracil in Colorectal Cancer through activating autophagy by stabilizing VCP

  • J Cancer. 2021 Feb 22;12(8):2317-2325. doi: 10.7150/jca.52158.
Hongze Sun 1 2,  Rangrang Wang 1,  Yuan Liu 1,  Haitao Mei 1,  Xueni Liu 1,  Zhihai Peng 1 3
Affiliations

Affiliations

  • 1 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • 2 Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.
  • 3 Department of General Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
PMID: 33758608 DOI: 10.7150/jca.52158
Abstract

Chemotherapy plays an important role in the treatment of patients with colorectal Cancer (CRC). However, the resistance to chemotherapy severely affects the prognosis of CRC patients and the mechanisms are still poorly understood. Our study investigated the role of Ubiquitin-Specific Protease 11 (USP11) in CRC chemotherapy and found that USP11 could induce resistance to 5-fluorouracil by activating Autophagy. A series of in vitro and in vivo experiments revealed that USP11 promoted Autophagy through AMPK/Akt/mTOR pathway via stabilizing valosin-containing protein (VCP). Overall, our study demonstrated that USP11 might be valuable to predict the chemotherapeutic sensitivity and improve the prognosis of CRC patients.

Keywords

5-fluorouracil; USP11; VCP; chemotherapy resistance; colorectal cancer.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z