2. Academic Validation
  3. An enzyme-responsive Gp1a-hydrogel for skin wound healing

An enzyme-responsive Gp1a-hydrogel for skin wound healing

  • J Biomater Appl. 2021 Oct;36(4):714-721. doi: 10.1177/08853282211012870.
Chunming Zhao 1,  Yangyi Dong 2,  Jialin Liu 2,  Hongxing Cai 2,  Zhouru Li 2,  Xiaoming Sun 2,  Wenjiang Yin 2,  Jingyuan Ma 2,  Hongmei Liu 3,  Shanshan Li 2
Affiliations

Affiliations

  • 1 Department of Human Anatomy, Xuzhou Medical University, Xuzhou, China.
  • 2 Jiangsu Medical Engineering Research Center of Gene Detection and Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, China.
  • 3 Institute of Nervous System Diseases, Xuzhou Medical University and Neurosurgery Department, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
PMID: 33906517 DOI: 10.1177/08853282211012870
Abstract

Faster recovery and fewer scars are ideal wound healing. We have demonstrated that the Cannabinoid Receptor 2 (CB2) agonist Gp1a is beneficial to skin wound healing, which inhibits inflammation and fibrogenesis while promoting re-epithelialization. However, the systemic administration is imprecise and overqualified for a local skin wound. Herein, we prepared Gp1a-gel using triglycerol monostearate (Tm) hydrogel and detected whether the Gp1a-gel worked effectively on mouse skin excision wounds. The results showed that Gp1a-gel might sustainably increase the CB2 for at least 8 days. It decreased inflammation and fibrogenesis while promoting wound enclosure and re-epithelialization. These results suggested Gp1a-gel may utilize as a potential formulation strategy to treat the skin wound.

Keywords

Gp1a; Wound repair; cannabinoid receptor 2; fibrogenesis; hydrogel; re-epithelialization.

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