2. Academic Validation
  3. Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus

Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus

  • Mar Drugs. 2021 May 19;19(5):281. doi: 10.3390/md19050281.
Gao-Yang Peng 1 2 3,  Tibor Kurtán 4,  Attila Mándi 4,  Jing He 5,  Zheng-Yu Cao 5,  Hua Tang 6,  Shui-Chun Mao 1,  Wen Zhang 2 3
Affiliations

Affiliations

  • 1 School of Pharmacy, Nanchang University, 461 Bayi Road, Nanchang 330006, China.
  • 2 School of Medicine, Tongji University, 1239 Si-Ping Road, Shanghai 200092, China.
  • 3 School of Pharmacy, Navy Medical University, 325 Guo-He Rd., Shanghai 200433, China.
  • 4 Department of Organic Chemistry, University of Debrecen, POB 400, H-4002 Debrecen, Hungary.
  • 5 State Key Laboratory of Natural Medicines, Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Long-Mian Ave., Nanjing 211198, China.
  • 6 Institute of Translational Medicine, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China.
PMID: 34069724 DOI: 10.3390/md19050281
Abstract

Three new p-terphenyl derivatives, named 4″-O-methyl-prenylterphenyllin B (1) and phenylcandilide A and B (17 and 18), and three new indole-diterpene Alkaloids, asperindoles E-G (22-24), were isolated together with eighteen known analogues from the fungi Aspergillus candidus associated with the South China Sea gorgonian Junceela fragillis. The structures and absolute configurations of the new compounds were elucidated on the basis of spectroscopic analysis, and DFT/NMR and TDDFT/ECD calculations. In a primary cultured cortical neuronal network, the compounds 6, 9, 14, 17, 18 and 24 modulated spontaneous CA2+ oscillations and 4-aminopyridine hyperexcited neuronal activity. A preliminary structure-activity relationship was discussed.

Keywords

coral-associated fungi; indole-diterpene alkaloids; p-terphenyl; secondary metabolites; spontaneous Ca2+ oscillations.

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