2. Academic Validation
  3. CD30L+ classical monocytes play a pro-inflammatory role in the development of ulcerative colitis in patients

CD30L+ classical monocytes play a pro-inflammatory role in the development of ulcerative colitis in patients

  • Mol Immunol. 2021 Oct;138:10-19. doi: 10.1016/j.molimm.2021.06.016.
Chenxue Mei 1,  Xiao Wang 2,  Fanxiang Meng 2,  Xiaoqing Zhang 2,  Lu Gan 3,  Yuanyuan Wang 4,  Xun Sun 5
Affiliations

Affiliations

  • 1 Department of Immunology, China Medical University, 110122, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province, PR China; Department of Gastroenterology Medicine, Sheng Jing Hospital of China Medical University, 110004, Shenyang, Liaoning Province, PR China.
  • 2 Department of Immunology, China Medical University, 110122, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province, PR China.
  • 3 Department of Gastroenterology Medicine, Jin Qiu Hospital of Liaoning Province, 110016, Shenyang, Liaoning Province, PR China.
  • 4 Department of Anesthesiology, The Fourth Affiliated Hospital, China Medical University, 110000, Shenyang, Liaoning Province, PR China. Electronic address: shetao1220@hotmail.com.
  • 5 Department of Immunology, China Medical University, 110122, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province, PR China. Electronic address: wsunxun1220@cmu.edu.cn.
PMID: 34329889 DOI: 10.1016/j.molimm.2021.06.016
Abstract

Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease that affects the large intestine and exhibits a relapsing and remitting course. It is a complex immune-mediated disease of the gastrointestinal tract that increases morbidity and negatively influences the quality of life. Although our previous studies have indicated that CD30L is involved in the adaptive immune response in UC, it remains unclear whether it participates in the innate immune response. Our results revealed that the CD30L level significantly increased in the circulating classical monocytes of patients with UC and showed a positive correlation with the severity of UC. CD30L may participate in monocyte-mediated inflammation in patients with UC through the activation of circulating classical monocytes. The present study provides insights into a marker of severity and a potential target for the development of immunological therapy of UC.

Keywords

CD30 ligand; Monocytes; Proinflammation; Ulcerative colitis.

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