2. Academic Validation
  3. Insulin-like growth factor binding protein-1 regulates HIF-1α degradation to inhibit apoptosis in hypoxic cardiomyocytes

Insulin-like growth factor binding protein-1 regulates HIF-1α degradation to inhibit apoptosis in hypoxic cardiomyocytes

  • Cell Death Discov. 2021 Sep 16;7(1):242. doi: 10.1038/s41420-021-00629-3.
Xiaoyan Tang 1,  Huilin Jiang 1,  Peiyi Lin 1,  Zhenhui Zhang 1,  Meiting Chen 1,  Yi Zhang 1,  Junrong Mo 1,  Yongcheng Zhu 1,  Ningning Liu 2 3,  Xiaohui Chen 4
Affiliations

Affiliations

  • 1 Department of Emergency, the Second Affiliated Hospital, Guangzhou Medical University, 510260, Guangzhou, Guangdong, China.
  • 2 Department of Emergency, the Second Affiliated Hospital, Guangzhou Medical University, 510260, Guangzhou, Guangdong, China. liuningning@gzhmu.edu.cn.
  • 3 Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, State Key Laboratory of Respiratory Disease, the Second Affiliated Hospital, Guangzhou Medical University, 510260, Guangzhou, China. liuningning@gzhmu.edu.cn.
  • 4 Department of Emergency, the Second Affiliated Hospital, Guangzhou Medical University, 510260, Guangzhou, Guangdong, China. cxhgz168@126.com.
PMID: 34531382 DOI: 10.1038/s41420-021-00629-3
Abstract

Hypoxia is important in ischemic heart disease. Excessive Insulin-like growth factor binding protein-1 (IGFBP-1) amounts are considered to harm cardiomyocytes in acute myocardial infarction. However, the mechanisms by which IGFBP-1 affects cardiomyocytes remain undefined. The present study demonstrated that hypoxia up-regulates IGFBP-1 and HIF-1α protein expression in cardiomyocytes. Subsequent assays showed that IGFBP-1 suppression decreased HIF-1α expression and inhibited hypoxia-induced Apoptosis in cardiomyocytes, which was reversed by HIF-1α overexpression, indicating that HIF-1α is essential to IGFBP-1 function in cellular Apoptosis. In addition, we showed that IGFBP-1 regulated HIF-1α stabilization through interacting with VHL. The present findings suggest that IGFBP-1-HIF-1α could be targeted for treating ischemic heart disease.

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