2. Academic Validation
  3. Structural characterisation and antitumor activity against non-small cell lung cancer of polysaccharides from Sanghuangporus vaninii

Structural characterisation and antitumor activity against non-small cell lung cancer of polysaccharides from Sanghuangporus vaninii

  • Carbohydr Polym. 2022 Jan 15;276:118798. doi: 10.1016/j.carbpol.2021.118798.
Xilin Wan 1,  Xin Jin 2,  Xinmin Wu 3,  Xue Yang 4,  Dongmei Lin 5,  Changtian Li 6,  Yongping Fu 6,  Yang Liu 6,  Xinze Liu 7,  Jianhua Lv 6,  Andrey A Gontcharov 8,  Hongmei Yang 7,  Qi Wang 9,  Yu Li 10
Affiliations

Affiliations

  • 1 International Cooperation Research Center of China for New Germplasm and Breeding of Edible Mushrooms, Jilin Agricultural University, Changchun 130118, China; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
  • 2 Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun 130024, China.
  • 3 Department of Neurosurgery, First Hospital of Jilin University, Changchun 130021, China.
  • 4 Cardiovascular Medicine and Cardiac Rehabilitation Center, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun 130021, China.
  • 5 Electric Diagnosis Department, Jilin Municipal Hospital of Traditional Chinese Medicine, Jilin 132000, China.
  • 6 International Cooperation Research Center of China for New Germplasm and Breeding of Edible Mushrooms, Jilin Agricultural University, Changchun 130118, China.
  • 7 Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
  • 8 Institute of Biology and Soil Science, FEB RAS, 100-letia Vladivostoka Prospect, 159, Vladivostok 690022, Russia.
  • 9 International Cooperation Research Center of China for New Germplasm and Breeding of Edible Mushrooms, Jilin Agricultural University, Changchun 130118, China. Electronic address: qiwang@jlau.edu.cn.
  • 10 International Cooperation Research Center of China for New Germplasm and Breeding of Edible Mushrooms, Jilin Agricultural University, Changchun 130118, China. Electronic address: yuli966@126.com.
PMID: 34823804 DOI: 10.1016/j.carbpol.2021.118798
Abstract

The medicinal fungus Sanghuangporus vaninii can be cultivated in large scale and has outstanding antitumour activity. In this study, water-soluble S. vaninii Polysaccharides (SVPs) were extracted from fruiting bodies. Four polysaccharide sub-fractions (SVP-W, SVP-1, SVP-2 and SVP-3) were isolated, with molecular weights from 90.50 kDa to 261.70 kDa, and all inhibited the proliferation of non-small cell lung Cancer cell lines A549, 95-D and NCI-H460, especially the acidic SVP-1. SVP-1 affected cell morphology and colony formation in NCI-H460 cells. It also promoted cell Apoptosis following nuclear fluorescence staining and flow cytometry. Methylation and nuclear magnetic resonance analyses revealed that SVP-1 is a heteroglycan with the main chain →4)-β-D-Glcp-(1 → 6)-β-D-Glcp-(1 → 6)-α-D-Galp-(1 → 6)-β-D-Glcp-(1→, and the branched chain α-D-Manp-(1 → 2)-α-D-Manp-(1 → 3)-β-D-Glcp-(1 → 3,6)-β-D-Glcp-(1→. The findings indicate that this natural acidic polysaccharide has potential for non-small cell lung Cancer therapy.

Keywords

Antitumour activity; Lung cancer; Polysaccharide; Sanghuangporus vaninii; Structure.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z