1. Academic Validation
  2. Satralizumab, Novel Interleukine-6 Inhibitor for Preventing Descending Thoracic Aorta Aneurysm Development

Satralizumab, Novel Interleukine-6 Inhibitor for Preventing Descending Thoracic Aorta Aneurysm Development

  • Cardiovasc Drugs Ther. 2021 Nov 26. doi: 10.1007/s10557-021-07294-9.
Amir Hossein Heydari 1 Sophia Heydari 2 Mohammad Esmaeil Heidari 3
Affiliations

Affiliations

  • 1 School of Medicine, Zanjan University of Medical Science, Zanjan, Iran. amhohe@gmail.com.
  • 2 Shahid Beheshti Hospital, Zanjan University of Medical Science, Zanjan, Iran.
  • 3 Department of Electrical Engineering, Henry Samueli School of Engineering, University of California, Los Angeles, CA, USA.
Abstract

Background: Descending thoracic aorta aneurysm (dTAA) has increasing incidence and, if left untreated, could lead to death. There is not any study of satralizumab treatment for preventing dTAA formation and progression.

Materials and methods: Forty male 10-week-old Rattus norvegicus were enrolled in the experiment. They were divided into four equal groups: dTAA treated with saline (dTAA-P) and dTAA treated with satralizumab (dTAA-S). One of the control groups was treated with saline (C-P), and the other was treated with satralizumab (C-S). Satralizumab and saline were used once every 2 weeks, subcutaneously 120 mg for 4 weeks. dTA diameter was measured at days 0, 3, 7, 14, 21, and 28.

Results: IL-6 level was measured on the 7th day that showed significantly increased IL-6 serum level in dTAA-P rats compared to C-P. Maximal dTA diameter (%MAD) was obtained at day 14, which was scientifically matched to the aorta aneurysm definition (>50% increase in diameter). From the seventh day, a significant difference in %MAD was observed between dTAA-P and dTAA-S groups. However, the %MAD of these two groups was significantly higher than control groups till the end of the 28th day.

Conclusion: Using an IL-6 Inhibitor agent to prevent dTAA formation and progression showed promising results. It suggests that using the IL-6 inhibitors in susceptible persons can be considered a lifesaving therapeutic approach.

Keywords

Aneurysm; IL-6 receptor antagonist; Interleukin-6; Rodent model of human disease; Satralizumab.

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